天然植物苦豆子生物碱衍生物对小鼠淋巴瘤和乳腺癌的抑制作用(英文)  

Inhibitive effects of derivative of natural alkaloid from Sophora alopecuroides on lymphoma and breast cancer in rats

作　　者：周则卫[1] 刘培勋[1] 李松年[1] 徐文清[1] 张荷清[1] 王月英[1] 刘正明[1] 

机构地区：[1]中国医学科学院中国协和医科大学放射医学研究所,天津市300192

出　　处：《中国临床康复》2004年第5期990-991,共2页Chinese Journal of Clinical Rehabilitation

基　　金：天津市自然科学基金资助项目(003804511)~~

摘　　要：目的:研究天然植物苦豆子的生物碱衍生物9002#对IRM-2纯系小鼠淋巴瘤及乳腺癌的体内抑瘤作用。方法:建立荷瘤小鼠模型,以腹腔给药方式给予2个不同剂量的药物水溶液,观察瘤质量和体质量,测定抑瘤率。结果:经重复试验,9002#有一定的抑瘤作用。对淋巴瘤,剂量50mg/(kg·d)×10天,抑瘤率51.3%～53.5%(t=4.04,3.30;P均<0.01);剂量150mg/(kg·d)×10天,抑瘤率31.3%～35.7%(t=2.22,2.49;P均<0.05)。对乳腺癌,剂量50mg/(kg·d)×10天,抑瘤率57.1%(t=2.63;P<0.01);剂量150mg/(kg·d)×10天,抑瘤率48.6%(t=2.19;P<0.01)。结论:9002#对IRM-2纯系小鼠移植肿瘤有一定的抑制作用,尤以50mg/(kg·d)×10天剂量组对移植瘤效果较明显,有潜在的临床应用价值。AIM:To investigate the inhibiting effects of 9002#,a derivative of alkaloids from Sophora alopecrokdes,on lymphoma and mammary adenoma. METHODS:Sixty three IRM 2 inbred strain mice were inoculated with lymphoma and mammary adenoma respectively.9002#,at the doses of 50 mg/kg per day×10 days and 150 mg/kg per day×10 days were injected intraperitoneally.The changes of body mass and tumor mass were scaled,and the inhibiting rates were analyzed. RESULTS:The lymphoma inhibiting rate of 9002# at the dosage of 50 mg/kg once a day×10 days was 51.3%-53.5%(t=4.04,3.30,P< 0.01),and that of 9002# at the dosage of 150 mg/kg once a day×10 days was 31.3%-35.7%(t=2.22,2.49,P< 0.05).The mammary adenoma inhibiting rate of 9002# at the dosage of 50 mg/kg once a day×10 days was 57.1%(t=2.63,P< 0.01),and that of 9002# at the dosage of 150 mg/kg once a day ×10 days was 48.6%(t=2.19,P< 0.01). CONCLUSION: 9002# has certain inhibiting effects on transplanting sarcomas in IRM 2 inbred strain mice,and the drug at the dosage 50 mg/kg once a day ×10 days is more effective on both sarcomas.9002# has potential value in clinical cancer treatment.

关 键 词：天然植物 苦豆子 生物碱衍生物 小鼠 淋巴瘤 乳腺癌 抑制作用 

分 类 号：R273.34[医药卫生—中西医结合] R273.79[医药卫生—中医肿瘤科]