心脉龙与香丹及参脉注射液对大鼠草鱼胆中毒早期肾脏损害的影响  

Effects of Xinmailong,Xiangdan and Shenmai Injection on early kidney damage induced by toxin of grass carp bile

作　　者：吴建新[1] 钮荣祥[1] 董丛丽[1] 

机构地区：[1]云南大理学院生理学与病理生理学教研室,云南大理671000

出　　处：《中西医结合学报》2004年第1期33-35,共3页Journal of Chinese Integrative Medicine

基　　金：云南省大理州科技局基金资助项目 (No .0 0 2 42 )

摘　　要：目的 :观察心脉龙、香丹、参脉注射液对大鼠草鱼胆中毒早期肾脏损害的影响 ,为中药治疗草鱼胆中毒所致的肾脏损害提供实验依据。方法 :SD大鼠 1次胃饲大理地区草鱼胆汁 (6ml/kg) ,复制草鱼胆中毒模型 ,10min后分别腹腔注射心脉龙、香丹或参脉注射液。结果 :上述中药均能降低血肌酐和血尿素氮的水平 ,增加肌酐清除率 ,减少近曲小管上皮细胞坏死及囊腔内有红细胞的肾小球数目 ,与对照组比较 ,P <0 .0 1。结论 :中药制剂心脉龙、香丹。Objective:To observe the effects of Xinmailong (XML), Xiangdan (XD) and Shenmai (SM) Injection on early kidney damage induced by toxin of grass carp bile (GCB) and provide experimental evidence for Chinese medicine in treating toxication of GCB. Methods:GCB (6ml/kg) was administered orally to adult SD rats to induce the model of GCB intoxication and a single intraperitoneal injection of XML, XD or SM was administered 10 min later. Results:It was found that the levels of blood creatinine and blood urea nitrogen were decreased and the creatinine clearance rate was increased by XML, XD or SM. Degenerated epithelial cells of proximal convoluted tubules and glomeruli containing red blood cells in saccular cavities were decreased as compared with the normal group (P <0.01). Conclusion:The Chinese medicine XML, XD and SM Injection have therapeutic effects on early kidney damage induced by toxin of GCB.

关 键 词：心脉龙 香丹 参脉注射液 大鼠 草鱼胆中毒 肾脏损害 肾疾病 

分 类 号：R285[医药卫生—中药学]