益气养阴法防治癌转移的实验研究  

Experimental study on Qi-replenishing and Yin-nourishing in inhibiting tumor metastasis

作　　者：李涌健[1] 

机构地区：[1]苏州市中医院肿瘤科,江苏苏州215003

出　　处：《中西医结合学报》2004年第1期49-52,共4页Journal of Chinese Integrative Medicine

基　　金：江苏省中医药管理局基金资助项目 (No.1997 2 3 11)

摘　　要：目的 :研究益气养阴中药的抗肿瘤转移作用 ,探讨中药防治癌转移的作用机制。方法 :5 0只小鼠分为益气组、养阴组、益气养阴组、化疗组和空白对照组 ,每组 10只。以小鼠Lewis肺癌模型及B16黑色素瘤模型为实验观察对象。观察瘤重抑制率、肺部转移灶、瘤组织组织型纤溶酶原激活物和血栓烷B2 的含量以及白细胞介素 2和肿瘤坏死因子 α的水平。结果 :益气养阴中药对Lewis肺癌和B16黑色素瘤的瘤重抑制率均为 4 2 .9%。益气养阴中药能明显降低Lewis肺癌、B16黑色素瘤荷瘤小鼠瘤组织血栓烷B2 和 6 酮 前列腺素F1α的含量 ,提高组织型纤溶酶原激活物、白细胞介素 2及肿瘤坏死因子 α的水平。结论 :益气养阴中药在抗癌转移过程中能最大限度地调动机体的抗癌能力 。Objective:To study the effect of Qi-replenishing and Yin-nourishing in inhibiting tumor metastasis. Methods:Fifty mice were randomly divided into replenishing Qi group, replenishing Yin group, replenishing Qi and Yin group, chemotherapy group and control group. Models of Lewis lung cancer and B 16 melanoma were observed in vivo. The tumor weight inhibiting rate, metastatic lung tumor, concentrations of t-PA and TXB 2 in tumor tissue and IL-2 and TNF-α in spleen were observed. Results:The tumor weight inhibiting rates of replenishing Qi and Yin group for Lewis lung cancer and B 16 melanoma were both 42.9%. Replenishing Qi and Yin could decrease the contents of TXB 2 and 6-keto-PGF 1α, and increase the levels of IL-2 and TNF-α. Conclusion:Replenishing Qi and Yin can promote the healthy energy to inhibiting tumor metastasis.

关 键 词：益气养阴法 防治措施 癌转移 中药 治疗 

分 类 号：R273[医药卫生—中西医结合]