阴极溶出伏安法测定血清中5-氟脲嘧啶(5-Fu)及其电极反应机理  

DETERMINATION OF 5-FLOUROURACIL IN SERUM BY CATHODIC STRIPPING VOLTAMMETRY AND MECHANISM OF ELECTRODE REACTION

作　　者：阎江丽[1] 吴守国[1] 蒲国刚 汪尔康[1] 

机构地区：[1]中国科学技术大学应用化学系,合肥230026

出　　处：《应用化学》1992年第1期37-41,共5页Chinese Journal of Applied Chemistry

基　　金：国家自然科学基金

摘　　要：用阳极富集和差分脉冲阴极溶出伏安法测定了血清中5-氟脲嘧啶(5-Fu)含量,用三氯乙酸作沉降剂消除了血清中电活性物质的干扰。研究结果表明,5-Fu可与汞电极阳极极化,产生的Hg(Ⅱ)在电极表面生成难溶化合物Hg-5-Fu,该化合物具有链状大分子结构。The differential pulse cathodic stripping voltammetry has been employed to determine the concentration of 5-flourouracil (5-Fu) in serum.The interferences of electroactive substanees in serum can be eliminated by trichloroacetic acid. It is shown that 5-Fu can combine with Hg(Ⅱ) generated by anodic polarization forming an insoluble complex on electrode surface, The Hg-5-Fu complex is deemed to be a macromolecule with chain structure.

关 键 词：5-氟脲嘧啶 血清 伏安法 

分 类 号：R446.11[医药卫生—诊断学]