二甲胺铂与含氮、硫羧酸的反应  

REACTIONS OF Pt(MeNH_2)_2(H_2O)_2^(2+) WITH ORGANIC ACIDS CONTAINING N AND S ATOM

作　　者：杨志勇[1] 杨振云[1] 刘秀梅[1] 胡皆汉[1] 

机构地区：[1]中国科学院大连化学物理研究所,大连116012

出　　处：《应用化学》1992年第6期85-88,共4页Chinese Journal of Applied Chemistry

摘　　要：自从抗癌药顺铂（cis-Pt（NH₃）₂Cl₂）被发现和应用以来,已合成了多种类似物。为了弄清这类药物的作用机理,有不少文献研究其活性组分cis-Pt（NH₃）₂（H₂O）₂²⁺与核苷、核酸的反应。已经知道氨基酸能携带含铂组分通过细胞膜。Reactions of Pt (MeNH_2)_2(H_2O)_2^(2+) with glycine,L-methionine, N-methyliminodiacetie acid and thiodiacetic acid were studied by pH potentiometry and ~13C NMR spectroscopy.The complex formation constants (logK) were 8.55, 8.64,8.05 and 3.68, respectively, as determined by pH titration at 37℃. The possible structures of the formed complexes were briefly discussed.

关 键 词：氨基酸 铂络合物 二甲胺铂 

分 类 号：O614.826[理学—无机化学]