叶绿素、血卟啉致动脉粥样硬化斑块光敏化作用对比研究  

Comparative Study of Photodynamic Therapy with Chlorophyll and Hematoporphyrin Derivatives in Laser Ahlation of Atherosclerotic Plaques

作　　者：邓永华[1] 余枢[1] 汪道文[1] 李正佳[2] 刘安平[2] 

机构地区：[1]同济医科大学同济医院 [2]华中理工大学光学研究所

出　　处：《应用激光》1992年第2期89-91,共3页Applied Laser

摘　　要：以荧光显微镜观察经生理盐水、叶绿素、血叶啉处理人尸粥样斑块及正常血管,发现叶绿素、血卟啉能选择性聚积于动脉粥样硬化斑块。以等量的Nd:YAG倍频激光能量照射,叶绿素、血卟啉处理组斑块激光消融涤度大于对照组斑块消融深度,P<0.01;提示叶绿素、血卟啉是Nd:YAG倍频激光血管成形术的理想光敏剂。Selective concentration within atherosclerotic plaques by chlorophyll and hematopor-phyrin derivatives were varifred with ultraviolet microscope in vitro. Postmortem human aortaswere exposed to equal total energy of double frequency Nd:YAG laser irradiation, there weremore extensive ablation in plaques treated with chlorophyll and hematoporphyrin derivatives com-pared with plaques treated with normal saline, P<0.01. Results indicated that chlorophyll andhematoporphyrin derivatives may be ideal photo-sensitizers for double frequency Nd:YAG laserangioplasty.

关 键 词：叶绿素 血卟啉 斑块 动脉粥样硬化 

分 类 号：R543.505[医药卫生—心血管疾病]