2-[N-甲基-N-(2-吡啶基)氨基]乙醇制备条件的优化  

Optimize of respond the term of 2-[N-methyl-N-(2-pyridine) amido]ethanol

作　　者：徐宏[1] 杨桂玲[2] 

机构地区：[1]南京化工职业技术学院,江苏南京210048 [2]江苏电大化工分校,江苏南京210048

出　　处：《化学工程师》2004年第2期8-10,共3页Chemical Engineer

摘　　要：2 -[N -甲基 -N -(2 -吡啶基 )氨基 ]乙醇是合成罗格列酮 (Rosiglitazone)的一种中间体。罗格列酮是新型噻唑烷二酮类胰岛素增敏剂 ,通过两轮优化设计 ,实验室小试得到了较好的反应条件 。N-methyl-N-(2-pyridine) amido]ethanol synthesize the Rosiglitazone of a the kind is intermediate. Rosiglitazone is a new thiazolidione insulins censitizer, its sour salt to come the already from the England Smithkling Beecham Plc (G.B) Company in 1999 years research to manufacture the success and pass by two optimizes the design,and pass the laboratory small tried to get the good reaction term produced to provide the foundation dataed for industrialization.

关 键 词：2-[N-甲基-N-(2-吡啶基)氨基]乙醇 制备 反应条件 优化 罗格列酮 胰岛素增敏剂 

分 类 号：TQ467.32[化学工程—制药化工]