硒和蛋氨酸缺乏对心肌损伤作用的实验研究  

THE EXPERIMENTAL STUDY ON MYOCARDIAL LESION INDUCED BY BOTH SELENIUM AND METHIONINE DEFICIENCY IN RATS

作　　者：曾宪惠[1] 迟月明[1] 许立庆[1] 万汇娟[1] 刘秀丽[1] 徐柏芬[1] 

机构地区：[1]哈尔滨医科大学克山病研究所,哈尔滨150086

出　　处：《营养学报》1992年第1期58-62,共5页Acta Nutrimenta Sinica

基　　金：国家自然科学基金

摘　　要：本文叙述了低硒条件下蛋氨酸缺乏对心肌的损伤作用。实验结果表明,低硒饲料能引起心肌超微结构改变,心肌细胞色素氧化酶和琥珀酸脱氢酶活性下降,全血和组织GSH-Px活性下降,血清和组织的丙二醛MDA值升高。而低硒和低蛋氯酸的复合作用导致上述测试指标明显改变,进一步加重心肌损伤。According to the level of selenium (Se) and methionine (Met) in diet, Wistar rats were randomly divided into 3 groups, group A (normal Se and normal Met); group B (Low Se and normal Met); group C (low Se and low Met). The animals were sacrificed after 8-week feeding. The results showed that the alteration of myocardial ultrastructure was slight in group B. Decreased activities of cytochrome oxidase and succinate dehydrogcnase of myocardial mitochonria and decreased activities of GSH-Px in the blood, heart and liver in group B were observed, as compared with those in group A. But the level of TBA was higher than that of group A.The above mentioned changes in group C were extremely apparent than group A or B, indicating both Se and Met deficiency in diet may concern the etiology of Keshan disease.

关 键 词：硒 心肌 蛋氨酸缺乏 

分 类 号：R459.3[医药卫生—治疗学]