维生素A促进伤口愈合的适宜剂量的研究  

A STUDY ON A SUITABLE DOSAGE OF VITAMIN A IN WOUND HEALING

作　　者：高兰兴[1] 许志勤[1] 金宏[1] 王宗印[1] 徐登云[1] 顾景范[1] 

机构地区：[1]卫生学环境医学研究所,天津300050

出　　处：《营养学报》1992年第1期33-37,共5页Acta Nutrimenta Sinica

摘　　要：本研究观察了大鼠手术以后,补给不同剂量的VA对血清VA、伤口愈合及胸腺的影响。术后每天补给VA6μg/100g bw的手术Ⅰ组,血清VA含量和胸腺重量均明显小于补给同样剂量的正常对照组。术后每天补给VA25μg/100gbw的手术Ⅱ组,不仅血清VA可维持在正常营养水平,而且胸腺也无明显变化,伤口愈合的组织形态学结构已接近正常大鼠的皮肤,伤口张力也显著大于手术Ⅰ组。术后每天补给VA50μg/100gbw的手术Ⅲ组,效果并不优于手术Ⅱ组。因此,VA促进大鼠伤口愈合的适宜剂量应为25μg/100g bw·d,约相当于正常供给量的4倍。The effects of vitamin A on wound healing and thymus weight were studied in postoperative rats. Serum vitamin A level was significantly lowered in rats (group I) received vitamin A 6μg · 100g bw-1·d-1. per os as.compared to the uninjured control received the same dose of vitamin A. The thymus in group I was significantly atrophic than the control. In rats received vitamin A 25μg·100g bw-1·d-1 (group Ⅱ), serum vitamin A level was kept normal and the thymus was unchanged. The histological change of the skin during wound healing nearly approached normal, and the tensile strength of the healed wound was markedly greater than in group Ⅰ. In rats received vitamin A 50μg·100g bw-1·d-1 (group Ⅲ), the effect on wound healing and the thymus was not better than group Ⅱ. A suitable dosage of vitamin A in wound healing was about 25μg·100g bw-1·d-1, i.e. 4 times the normal allowances of the rat.

关 键 词：维生素A 伤口愈合 胸腺 剂量 

分 类 号：R459.3[医药卫生—治疗学]