黄连降糖片粉碎和提取工艺研究  

Study on pulverization and extraction of Huanglianjiangtang Tablets

作　　者：叶福媛[1] 吴倩[1] 张钰泉[1] 毛泉明[1] 

机构地区：[1]上海中医药大学,上海201203

出　　处：《中成药》2004年第2期94-96,共3页Chinese Traditional Patent Medicine

摘　　要：目的 :确定黄连降糖片 (黄连、大黄等 )粉碎和提取工艺条件。方法 :采用气流粉碎技术 ,以大黄素和大黄酚含量为指标 ,考察大黄粉碎粒度对含量的影响 ;采用正交实验设计 ,以盐酸小檗碱含量为指标 ,优选黄连提取工艺条件。结果 :粉碎粒度以 10 μm为好 ;提取工艺确定为乙醇浓度 5 0 %浸泡时间 4 0min ,提取时间 2h ,回流次数 3次。结论 :该工艺提取的有效成分含量高 ,适合于大生产。AIM: To make the optimum process conditions of extracting and grinding for Huanglianjiangtang Tablets (Rhizoma Coptidis, Radix et Rhizoma Rhei, etc.). METHODS: Applying fluid jet mill to the root of Radix et Rhizoma Rhei and adopting emodin and chrysophanol as markers, degree of grinding on herbs was studied, optimum extraction of Rhizoma coptidis with Berberine as marker was investigated by orthogonal design. RESULTS: Optinum processing condition was as follow, powdered herbs with diameter less than 10μm macerated in 50% ethanol for 40min , reflux extraction three times and 2hr per time. CONCLUSION: The optimum processes result in high content of active constituents. These processes can be applied rightly in mass production.

关 键 词：黄连 大黄 提取工艺 粉醉工艺 

分 类 号：R282.2[医药卫生—中药学]