胚胎源性干细胞特性及组织工程应用前景  

Characteristic of embryo-derived stem cells and its'prospect in tissue engineering

作　　者：王晓云[1] 丛笑倩[1] 刘伟[1] 曹谊林[1] 

机构地区：[1]上海第二医科大学附属第九人民医院整复外科组织工程实验室，200011

出　　处：《国外医学（生物医学工程分册）》2004年第1期5-8,共4页Foreign Medical Sciences(Biomedical Engineering Fascicle)

摘　　要：种子细胞来源不足是目前限制组织工程发展的瓶颈问题,而免疫排斥则是限制器官和组织移植成功的一个重要原因。胚胎干细胞的多向分化潜能和无限扩增能力,结合细胞核移植技术使胚胎源性干细胞有希望同时解决这两个难题。本文综述了几种胚胎来源干细胞以及它们的生长特性、表面标志和体外诱导分化,并对其组织工程应用前景进行展望。The key issue that restricts the development of tissue engineering is the lake of seed cells. Immune rejection is a vital reason that prevents the success from organ and tissue transplantation. Because embryonic stem cells ES possess the totipotentiality and the ability to proliferate indefinitely in vitro. ES cells are expected to solve these two problems with the technique of nuclear transplantation. In this paper we review the origin of different kinds of embryo-derived stem cells and their growth property, surface marker and in vitro differentiation, and their prospects of application in tissue engineering as a new source of seed cells. [

关 键 词：胚胎源性干细胞 胚胎生殖细胞 原始生殖细胞 组织工程 种子细胞 细胞分化 细胞核移植 

分 类 号：R318.0[医药卫生—生物医学工程]