双取代乙二胺金属配合物的合成及抗菌活性  

Synthesis and antibacterial activities of the metal complexes of bis-substituted ethyldiamine

作　　者：杨树平[1] 高乌恩[1] 吴冬梅[1] 田杰[1] 

机构地区：[1]内蒙古医学院药学系,内蒙古呼和浩特010059

出　　处：《中国现代应用药学》2004年第1期16-18,共3页Chinese Journal of Modern Applied Pharmacy

基　　金：内蒙古自然科学基金资助课题NO .980 5 3

摘　　要：目的　设计合成一系列双取代乙二胺过渡金属配合物并寻找抗菌活性药物。方法　以N ,N′ 双取代乙二胺为配体合成过渡金属配合物 ,并进行体外抑菌活性筛选。结果　合成了 6个 (Ⅲ1 6)新配合物 ,其结构经红外光谱、元素分析确证。结论　初步抑菌实验表明 ,合成的配合物对多种菌株有明显的抑制活性 ,有进一步研究的价值。OBJECTIVE A series of the complexes of bis-substituted ethyldiamine with transitional metal had been designed and synthesized for seeking antibacterical agents. METHOD The complexes have been prepared from N,N'-bis-substituted ethyldiamine and transitional metal, their antibacterical activities have been screened by test.RESULTS Six new complexes have been synthesized and their structures were identified by IR spectra and elementary analysis.CONCLUSION The results showed these complexes displayed significant antibacterical activities in primay treatment of many types of bacteria.

关 键 词：N N’-双取代乙二胺 配合物 抗菌活性 过渡金属 

分 类 号：TQ460.6[化学工程—制药化工] R978[医药卫生—药品]