前列腺素E_1脂微球载体制剂治疗慢性重型肝炎的临床研究  

Clinical study of Lipo PGE_1 on chronic severe hepatitis

作　　者：顾慧华[1] 田力[1] 薛来英[1] 

机构地区：[1]杭州市第六人民医院,浙江杭州310014

出　　处：《中国现代应用药学》2004年第1期69-71,共3页Chinese Journal of Modern Applied Pharmacy

摘　　要：目的　探讨前列腺素E1脂微球载体制剂 (LipoPGE1)治疗慢性重型肝炎 6 0例临床疗效观察。方法　选择本院 2 0 0 0年 12月至 2 0 0 1年 11月收治的慢性重型肝炎 12 0例 ,随机分为前列腺素E1脂微球制剂治疗组 6 0例和对照组 (综合治疗组 ) 6 0例。治疗组为前列腺素E1脂微球制剂 2 0 μg静注 ,每日一次 ,连续 4周观察疗效。 结果　前列腺素E1脂微球制剂组对慢重肝早中期肝功能 (ALT、TBIL、CHE)的改善疗效明显优于对照组 ,但晚期组二者疗效无显著差异。结论　LipoPGE1治疗慢性重型肝炎宜尽早使用 ,越早效果越好 ,其为治疗重型肝炎开拓了良好的前景。OBJECTIVE To observe the clinical effect of the Lipo PGE 1 in 60 patients with chronic severe hepatitis. METHOD 120 cases of patients were divided into two groups, Lipo PGE 1 group with 60 patients and the control group with the other 60 patients. Lipo PGE 1 group was daily administed with Lipo PGE 1 by intravenous drop infusion at a dosage of 20μg. The treatment was lasted for at least 4 weeks.RESULTS Lipo PGE 1 group had obviously better than the controls in the early and middle period of chronic severe hepatitis. But there was no significant difference in the endly chronic severe hepatitis. CONCLUSION Lipo PGE 1 should be applied as early as possible in the treatment of chronic severe hepatitis. Lipo PGE 1 is expected to be widely used to treat severe type hepatitis in the near future.

关 键 词：前列腺素E1脂微球载体制剂 慢性重型肝炎 

分 类 号：R977[医药卫生—药品] R512.6[医药卫生—药学]