HIV-1感染者及其密切接触者HIV-1抗性基因的研究  

Study on HIV-1 anti-gene of people infected with HIV-1 and their consanguineous contacters

作　　者：张静[1,2] 于修平[1] 李盛长 宋长芹[4] 傅继华[5] 尤向东[5] 

机构地区：[1]山东大学医学院微生物学教研室 [2]山东省疾病预防控制中心艾滋病防治所,山东济南250000 [3]济南市长清区中医院 [4]山东大学齐鲁医院 [5]山东省疾病预防控制中心艾滋病防治所

出　　处：《山东大学学报（医学版）》2004年第1期50-53,共4页Journal of Shandong University:Health Sciences

基　　金：山东省医药卫生科技发展计划青年基金(有资36号)

摘　　要：目的:研究CCR2-64I、SDF1-3'A2种HIV-1抗性基因在山东省HIV-1感染者及其密切接触者中的分布,以及它们对艾滋病病程进展和人群易感性的影响。方法:利用体外扩增PCR和限制性片段长度多态性分析RFLP检测目标人群中的HIV-1抗性基因,用统计学方法分析基因分布频率与病程进展和易感性的关系。结果:CCR2-64I、SDF1-3'A的突变频率分别为23.64%、23.94%,含SDF1-3'A1的患者平均潜伏期为(8.33±1.16)年,含CCR2-64I患者平均潜伏期为(8.94±1.17)年,野生纯合子患者为(7.42±1.33)年。结论:本研究首次阐明了CCR2-64I、SDF1-3'A在山东省HIV-1感染者及其密切接触者中分布的特点,并发现2种抗性基因的存在均可延缓感染者的病程。Objective: To study the effect and the distribution of HIV-1 anti-gene (CCR2-64I?SDF1-3'A) among people infected with HIV-1 and their consanguineous contacters. Methods: The anti-gene (CCR2-64I?SDF1-3'A) was detected by PCR and RFLP, and the relation between anti-gene and disease progression was analyzed by statistical method. Results: The allelic frequencies of CCR2-64I and SDF1-3'A were 23.64% and 23.94% respectively,and their polymorphism conformed to the Hardy-Weinberg balance distribution. The incubation periods for AIDS patients with SDF1-3'A1?CCR2-64I and wild type were 8.33±1.16, 8.94±1.17 and 7.42±1.33 years, respectively. Conclusion: The distribution characteristic of CCR2-64I and SDF1-3'A among people infected with HIV-1 and their consanguineous contacters in Shandong province was first illustrated, and the 2 HIV-1 anti-genes might be hehpful in delaying disease progression of AIDS patients.

关 键 词：人免疫缺陷病毒I型 受体 CCR2 抗性基因 

分 类 号：R512.91[医药卫生—内科学]