胶原材料在药物缓释和组织工程中的研究进展  

STUDY STATUS OF COLLAGEN-BASED BIOMATERIALS IN DRUG RELEASE AND TISSUE ENGINEERING

作　　者：王碧[1] 王坤余[1] 叶勇[1] 程劲[2] 但卫华[1] 张廷有[2] 

机构地区：[1]四川大学皮肤组织工程研究室,成都610065 [2]皮革化学与工程教育部重点实验室

出　　处：《中国修复重建外科杂志》2004年第2期112-114,共3页Chinese Journal of Reparative and Reconstructive Surgery

基　　金：国家高技术研究发展计划 (863)资助项目(2 0 0 1 AA32 0 60 9)~~

摘　　要：目的　介绍胶原材料在药物缓释和组织工程中的研究新进展。　方法　广泛查阅近年相关文献并进行回顾与综合分析。　结果　胶原材料在药物缓释与组织工程中的应用研究已取得明显进展 ,胶原材料已成为组织工程研究的热点之一。一些胶原基质新型药物缓释系统和新型组织工程材料已进入临床论证阶段 ,将促进胶原材料在组织修复中的临床应用。　结论　胶原材料在药物缓释、尤其是组织工程领域具有广阔的应用前景。除将胶原适当交联处理或与其它天然或合成高分子复合外 ,今后的研究中还应注重利用化学修饰改善胶原性能 ,通过将性质不同的支链接枝到胶原大分子上 ,赋予胶原新的特性 ,从而研制出新一代组织工程材料。Objective To introduce the development of the collagen materials in drug release and tissue engineering. Methods Literature review and complex analysis were adopted. Results In recent years, some good progress has been made in the studies of collagen, and study on collagen-based materials has become an investigative hotspot especially in tissue engineering. Some new collagen-based drug delivery and engineered materials have come into clinically-demonstrated moment, which will promote their clinical applications in tissue repairs. Conclusion Collagen has been considered a good potential material in drug release, especially in the tissue-engineering field. To give collagen new characters we should pay more attention to grafting with different function branches through chemistry technique in the future work, except moderate cross-linking treatment or commingling with other nature or synthesized macromolecules.

关 键 词：胶原 生物材料 药物缓释 组织工程 活性人工皮肤 骨骼替代物 胶原蛋自 

分 类 号：R94[医药卫生—药剂学] R318[医药卫生—药学]