海南地区人群中FⅩⅢ Val 34 Leu多态性的研究  

Val 34 Leu Polymorphism of Factor Xffl Gene in Populations in Hainan, China

作　　者：王巍[1] 廖小平[2] 李巍景[3] 姚震[3] 苏雨江[4] 杨志刚[5] 陈晓丹[6] 龙志刚[2] 陈莫水[2] 黄世雄[2] 文国强[2] 郑雅文[2] 陆仕娟[4] 刘国勋[5] 程爽[5] 包承鑫[7] 蔡望伟[1] 

机构地区：[1]海南医学院生物化学教研室 [2]海南省人民医院神经内科 [3]海南医学院附属医院心血管内科 [4]海口市人民医院心血管内科 [5]广东医学院附属医院血液研究室 [6]海南医学院附属医院检验科 [7]中国医学科学院血液研究所

出　　处：《血栓与止血学》2004年第1期5-7,共3页Chinese Journal of Thrombosis and Hemostasis

基　　金：国家自然科学基金(No.30060037);教育部科学技术研究重点项目(No.03147);广东省卫生厅科研项目(B2000121)

摘　　要：目的:研究海南地区汉族人群、黎族人群、脑梗死患者、冠心病患者FⅧ val 34Leu分布特点。方法:用聚合酶链反应、限制性片段长度多态性分析及核苷酸顺序测定检测205名汉族正常人、236名黎族正常人、196例脑梗死患者、188例冠心病患者(心肌梗死/非心肌梗死,55/133)FⅩⅢA链 Val 34 Leu多态性。结果:汉族人群、黎族人群、脑梗死组未发现Val 34 Leu多态性,在冠心病组中发现1例Val 34 Leu杂合子。结论:FⅧ Val 34 Leu变异在中国人群中不是多态性,与缺血性心脑血管疾病没有关联,不是中国人群中防止动脉血栓性疾病的保护性因素。Objective:To investigate the Val 34 Leu polymorphism in factor ⅩⅢ A subunit gene in the general populaions of Han nationality and Li nationality and in the patients with brain infarction( BI) and coronary heart dis-ease(CHD) in Hainan, China. Methods: The Val 34 Leu polymorphism was detected by polymerase chain reaction , restriction fragment length and DNA sequencing in the unrelated samples of 205 individuals of Han nationality, 236 individuals of Li nationality, 196 BI patients and 188 CHD patients(myocardial infarction/no myocardial infarction,55/133). Results: No Val 34 Leu polymorphism was found in the general populations of Han and Li nationalities and in the BI patient group. One heterozygote of Val 34 Leu was found in the CHD patient group. Conclusion: Val 34 Leu variation is not polymorphic and not associated with ischemic brain and heart disease in the Chinese population. 34 Leu allele is not a protective factor against the development of arterial thromboembolic disease in the Chinese population.

关 键 词：海南地区 凝血因子FⅧ Val 34 Leu多态性 血液凝固 脑梗死 

分 类 号：R55[医药卫生—血液循环系统疾病]