玫瑰糠疹患者T细胞亚群检测及意义探讨  

Analysis of T Cell Subsets in Patients with Pityriasis Rosea and Its Significance

作　　者：孙晓杰[1] 郭英军[2] 刘文力[1] 李铁男[1] 赵桂兰[1] 王玉华[1] 黄精华[1] 

机构地区：[1]沈阳市第七人民医院皮肤科,沈阳110003 [2]辽宁省人民医院皮肤科,沈阳110015

出　　处：《中国中西医结合皮肤性病学杂志》2003年第2期87-88,共2页Chinese Journal of Dermatovenereology of Integrated Traditional and Western Medicine

摘　　要：目的探讨玫瑰糠疹发病中外周血T淋巴细胞的变化。方法应用免疫组化技术对52例急性期及32例恢复期玫瑰糠疹患者的外周血T细胞亚群进行检测。结果玫瑰糠疹患者外周血CD8+百分比急性期明显高于恢复期(t=7.83,P<0.01),CD4+/CD8+比值明显降低(t=8.95,P<0.01),CD4+百分比急性期与恢复期无明显变化(t=1.43,P>0.05)。结论实验说明玫瑰糠疹急性期免疫细胞间的正常比例发生变化。急性期CD8+比例明显增高,说明Ts和(或)Tc细胞功能明显增强,这是否与抗病毒免疫的增强有关,尚待进一步研究。Objectives To investigate the changes of peripheral T lymphocytes in patients with pityriasis rosea.Methods T cell subsets in52acute and32convalescent patients with pityriasis rosea were detected by staining of im-munohistochemistry.Results The results showed that the proportion of CD8 + T lymphocytes are significantly higher(t=7.83,P<0.01)and the CD4 + /CD8 + ratio are significantly lower(t=8.95,P<0.01)in acute pityriasis rosea patients in con-trast with the convalescent.But the CD4 + T lymphocytes have no significant changes both in the acute and convalescent.Conclusion Our observations indicate that the subsets of T lymphocytes should be changed in acute pityriasis rosea.Whether or not the increased CD8 + T lymphocytes had any relationship with virus infection and participated in the patho-genesis should be further investigated.

关 键 词：玫瑰糠疹 T细胞亚群 抗病毒免疫 病毒感染 

分 类 号：R758.64[医药卫生—皮肤病学与性病学]