安太胶囊治疗骨质疏松症168例  

Effects of Antai capsule on women with postmenopausal osteoporosis

作　　者：王四旺[1] 郑本端 孙纪元[1] 谢艳华[1] 

机构地区：[1]第四军医大学科研部药物研究所,陕西西安710033 [2]湖北省鄂州市药品鉴定所,湖北鄂州436003

出　　处：《第四军医大学学报》2003年第14期1324-1327,共4页Journal of the Fourth Military Medical University

摘　　要：目的 :根据WHO的骨质疏松诊断标准 ,采用双能X射线骨密度仪 ,临床诊断为原发性骨质疏松症 (16 8例 ) ,按双盲对照实验分组 ,随机分成安太胶囊 +钙尔奇D、Ipr+钙尔奇D和钙尔奇D 3组 ;观察安太胶囊等试药对原发性骨质疏松症的效果 .方法 :采用放射免疫分析方法 ,检测原发性骨质疏松症患者治疗前后血清中卵泡生成素 (FSH)、黄体生成素 (LH)、雌二醇 (E2 )和骨密度 (BMD)的变化值 .结果 :①安太胶囊 +钙尔奇D试治 6 5例绝经后妇女原发性骨质疏松症 ,显效 4 8(73.8% )例 ,有效 15 (2 3.1% )例 ,总有效率为 96 .9% ,且无毒副反应 ;其疗效明显优于钙尔奇D片和Ipr(雌激素替代 ) +钙尔奇D .②安太胶囊 +钙尔奇D治疗后FSH ,LH ,E2 水平较治疗前分别提高 2 2 .7% ,35 .7%和 35 .2 % (P <0 .0 1) ;钙尔奇D片和Ipr+钙尔奇D作用不明显 .结论 :①安太胶囊具有明显改善骨质疏松的作用 .②因为安太胶囊能显著升高血清FSH ,LH ,E2 水平 ,提高卵巢功能 ,提示安太胶囊治疗骨质疏松症的机制可能与其改善或调节机体下丘脑 垂体 卵巢功能轴有关 .AIM: To observe the effects of Antai capsule (ATC) on womens post menopausal osteoporosis. METHODS: One hundred and sixty eight women with post menopausal osteoporosis, diagnosed by XR 36 dual energy X ray absorptionetry (DEXA) according to the standard of WHO, were divided randomly into three groups: ATC, Ipriflavone and control. The changes of FSH, LH, E2 and BMD were detected using the radioimmunological assay. RESULTS: Among the 65 patients of ATC treated with ATC, significant effects were found in 48 and good effects in 15, with the total effective rate was 96.9%. Estrogen and BMD obviously increased ( P <0.01). But Ipriflavone had many side effects such as sour regurgitation, discomfort in stomach and hectic fever. CONCLUSION: It is indicated that ATC can increase the level of estrogen and bone mineral density by systematic regulation. Its curative effects were better than that of calcium with vitamin D and Ipriflavone.

关 键 词：安太胶囊 骨质疏松 雌二醇 骨密度 依普拉封 

分 类 号：R285.5[医药卫生—中药学]