SARS患者外周血CD4^+CD8^+T淋巴细胞的变化  

Changes of CD4^+ and CD8^+ in T cell in peripheral blood in SARS

作　　者：程涛[1] 伍伟玲[1] 李灼亮[1] 罗显荣[1] 刘树人[1] 刘惠萍[1] 郑曲波[1] 谢庆[1] 

机构地区：[1]解放军第458医院传染科,广州510602

出　　处：《中华急诊医学杂志》2003年第6期376-377,共2页Chinese Journal of Emergency Medicine

摘　　要：目的　观察严重急性呼吸综合征 (severeacuterespiratorysyndrome,SARS)患者外周血CD4 + 和CD8+ T淋巴细胞的变化 ,探讨SARS患者机体的免疫状况。方法　 1 0位健康人 (对照组 )和 1 3例确诊为SARS患者于发病第 1、 2、 3、 4周采静脉血 ,用流式细胞仪检测CD4 + 、CD8+ T淋巴细胞。结果　与对照组比较 ,SARS患者从发病 1至 4周外周血CD4 + 、CD8+ T淋巴细胞百分比均有不同程度的降低 ,以病程发展的 2周左右为最明显。结论　SARS患者外周血CD4 + 、CD8+ T淋巴细胞有不同程度的降低 。Objective To observe the changes of CD4 + and CD8 +T cell in peripheral blood,and to explore the immune response in patients with SARS.Methods Consecutive blood samples from 13 patients with SARS and 10 healthy volunteers (serving as control group were collected.The CD4 + and CD8 + in T cell in peripheral blood were determined by flow cytometry.Results Compared with control group,the CD4 +and CD8 + in T cell in patients with SARS significantly decreased from one to four weeks,especially the second week.Conclusion There is an abnormal immune response in patients with SARS.The CD4 + and CD8 + in T cell in peripheral blood decrease. [

关 键 词：SARS 外周血 严重急性呼吸综合征 T淋巴细胞 治疗 传染病 

分 类 号：R511.9[医药卫生—内科学]