部分液体通气对吸入性损伤犬肺组织病理学的影响  

Effects of partial liquid ventilation(PLV)on histopathology of dog's lung with inhalation injury

作　　者：王联群[1] 郭光华[2] 钱克俭[1] 赵为禄[1] 朱峰[2] 熊龙[2] 

机构地区：[1]江西医学院第一附属医院ICU,南昌330006 [2]江西医学院第一附属医院烧伤中心,南昌330006

出　　处：《中华急诊医学杂志》2003年第12期805-807,I001,共4页Chinese Journal of Emergency Medicine

基　　金：国家自然科学基金资助项目 (3 9760 0 73 );江西省主要学科跨世纪学术和技术带头人培养计划资助课题

摘　　要：目的　研究部分液体通气 (PLV)对吸入性损伤犬肺组织病理学的影响。方法　将 16只犬经蒸气吸入造成吸入性损伤模型 ,并随机分为对照组和治疗组。所有动物行机械通气 ,伤后 1 5hPLV治疗组给予氟碳 ,剂量为 12ml/kg ,伤后 3h放血致死动物 ,取肺组织分别进行光镜和电镜下的组织病理学观察。结果　与对照组比较 ,PLV治疗组肺组织充血、水肿、中性粒细胞浸润明显减轻 ,血管内皮细胞和肺泡细胞损伤轻。结论　PLV能减轻吸入性损伤的肺组织损伤 ,具有抗炎作用。Objective To investigate the effect of partial liquid ventilation(PLV) lung histopathology in dogs with halation injuries.Methods Sixteen dogs with stream inhalation injury were randomly divided into control group and treatment group.All the dogs received conventional mechanical ventilation.In PLV group,12 ml/kg perfluorodecalin was slowly injected into lungs at 1 5 h after injury.All the dogs were killed at 3 h after injury.Lung histopathological changes were observed with the optical microscope and electron microscope.Results The pathological changes of congestion,edema and neurophile granulocyte infiltration of lung in PLV group was less than those in the control group.The PLV group had less lesios in angioendothelial cells and alveolar cells.Conclusion PLV may allieviate the histopathological changes after inhalation injury and has anti-inflammatory function.

关 键 词：液体通气 吸人性损伤 犬 肺组织 病理学 PLV 治疗 

分 类 号：R644[医药卫生—外科学]