调Q开关紫翠宝石激光治疗脂溢性角化病疗效观察  

Efficacy of Q-switched Alexandrite laser in seborrheic keratosis

作　　者：左亚刚[1] 王家璧[1] 王宏伟[1] 姜国调[1] 冯景春[1] 刘方[1] 

机构地区：[1]中国医学科学院中国协和医科大学北京协和医院皮肤科,100730

出　　处：《中华医学美学美容杂志》2003年第2期87-89,共3页Chinese Journal of Medical Aesthetics and Cosmetology

摘　　要：目的　探讨调Q开关紫翠宝石激光机治疗脂溢性角化病的疗效。方法　采用美国赛诺秀公司调Q开关闪光灯泵浦紫翠宝石激光机 ,波长 75 2nm ,治疗 119例脂溢性角化患者。结果　 119例中有 67例可评价疗效 ,其中男 15例 ,女 5 2例 ,年龄 3 1～ 71岁 ,平均 ( 5 4.8± 12 .5 )岁 ,病程 1～ 2 1年。所有患者均经 1～ 3次治疗 ,经 1次治疗 5 0例 ( 74.6% ) ,2次治疗 14例 ( 2 0 .9% ) ,3次治疗 3例 ( 4.5 % ) ;痊愈 17例 ( 2 5 .4% ) ,显效 2 5例 ( 3 7.3 % ) ,有效 17例 ( 2 5 .4% ) ,无效 8例 ( 11.9% ) ,总有效率 62 .7% ,治疗 1次有效率 5 8%。无色素沉着、色素减退和瘢痕形成。结论　调Q开关紫翠宝石激光机治疗脂溢性角化病安全 ,有效 。Objective Seborrheic keratosis are very common dermatosis occurred in the fourth to fifth decade. Recently, some encouraging results in the treatment of melain-related lesions, such as Ota`s nevus, tatoos, cafe spots, have been obtained using the Q-switched Alexandrite laser, but no reports were found in treating seborrheic keratosis. Our purpose was to assess the clinical outcomes induced by the Q-switched Alexandrite laser at 752nm. Methods Total 119 cases of seborrheic keratoses , aged from 31-76years, were treated with the Q-switched Alexandrite laser (model HT-10, Cynosure Laser Corp, USA. wavelength 752nm, pulse width 45-75ns). The energy was adjusted to 7.1-8.5J/cm 2 according to the charateristics of the lesions. The interval of two treatment was 1.5-3 months. No special care was needed. Results Sixty-seven of the 119 patients were evaluated after treatment (men 15 cases, women 52 cases, aged from 31～71 years, and course from 1 to 21 years). All the patients were treated by 1-3 times. The number of cases treated by 1, 2, and 3 times was 50 (74.6 %), 14 (20.9 %) and 3 (4.5 %), respectively. The degree of clearing was: complete clearing (17 cases, 25.4 %), significant improvement (25 cases, 37.3 %), moderate improvement (17 cases,25.4 %) and no change or mild improvement (8 cases,11.9%). The total rate of improment was 62.7%, while the improvement rate after 1 treatment was 58%. The efficacy was correlated with the area of the lesions. No side effects, such as hyperpigmentation and scars, were found. Conclusions This clinical data demonstrate the Q-switched Alexandrite laser is a safe and effective method for treatment of seborrheic keratosis and deserves to be used widely.

关 键 词：脂溢性角化病 调Q开关紫翠宝石激光机 安全性 老年人 作用机制 

分 类 号：R454.2[医药卫生—治疗学]