高密度脂蛋白对老年人冠心病的保护作用  

Apparent protective effect of high density lipoprotein against coronary heart disease in the elderly

作　　者：李健斋[1] 陈曼丽[1] 王抒[1] 董军[1] 曾平[1] 侯鲁维[1] 

机构地区：[1]北京医院卫生部北京老年医学研究所,100730

出　　处：《中华医学杂志》2003年第10期827-831,共5页National Medical Journal of China

摘　　要：目的　分析高密度脂蛋白胆固醇 (HDL C)水平与急性心肌梗死 (AMI)及冠心病 (CHD)死亡的关系 ,及高HDL水平对CHD的保护作用。方法　长期随访 12 11例老年离休干部 ,平均年龄入组时为 70± 9岁 ,终点 80± 9岁。随访时间为 1986～ 2 0 0 0年 ,平均随访 11 2年。按HDL C水平分为低 (<1 0 3mmol/L)中 (正常 ,1 0 3～ 1 5 6mmol/L)及高 (>1 5 6mmol/L) 3组 ,比较各组中AMI事件及CHD死亡率的差异。结果　随访期间累计发生CHD事件 (大都为AMI) 2 14例 ,其中死亡 89例 ,其他原因死亡 30 8例。HDL C从低水平组升至正常水平组时 ,AMI减少 4 0 % ,CHD死亡减少 5 3% ;从正常水平组升至高水平组时 ,AMI减少 5 6 % ,CHD死亡减少 5 0 %。单独将血脂正常 (总胆固醇 <5 17mmol/L、甘油三酯 <1 6 9mmol/L)的病例 (4 11例 )做统计分析 ,虽然低HDL C的致病作用仍很明显 ,但HDL C在正常与高水平时 ,发病与死亡数减少极明显。结论　对于老年人的AMI发病和CHD死亡 ,低HDL C仍是明显的独立危险因素 ,高HDL C水平对冠状动脉病的保护作用极为显著。在血脂不高的情况下 ,HDL对冠状动脉的保护作用更强。Objective To evaluate the relationship between the level of high-density lipoprotein cholesterol (HDL-C) and acute myocardial infarction (AMI) events and coronary heart disease (CHD) death, and to explore the protective effect of high level HDL against CHD in the elderly Chinese. Method A prospective study was done upon 1 211 retired cadres, 92% of which were males, enrolled in succession since 1986, aged 70±9 on average when being enrolled and aged 80±9 on average by the end of the study. During a follow up study with an average duration of 11.2 years, till the year 2000 or a specific subject died of CHD or other disease, all the participants received yearly physical examination and blood chemistry survey. CHD risk factors were screened by logistic regression analysis. According to their HDL-C levels, the subjects were divided into 3 groups: low HDL-C (<1.03 mmol/L), medium HDL-C (1.03-1.56 mmol/L), and high HDL-C (>1.56 mmol/L) groups. The differences in AMI event and CHD death in each group were analyzed. Results 411 of the subjects were with normal blood lipid (normal blood lipid group, total cholesterol <5.17 mmol/L, triglyceride <1.69 mmol/L), 338 subjects were basically healthy (basically healthy group), and 214 subjects developed CHD during the follow-up (CHD group). 23.2% of the subjects could be included in the low HDL-C group, 68.7% in the medium HDL-C group, and 68.5% in the high HDL-C group. The low HDL-C rate was 16.9% in the basically healthy group and 35.0% in the CHD group ( P =0.000 165). The high HDL-C rate was 12.4% in the basically healthy group and 3.3% in the CHD group ( P =0.000 645). During the follow up study, 214 cumulative attacks of acute coronary syndrome (mostly AMI) were recorded with 89 deaths. 308 cases died of other diseases. The AMI event rate and CHD death rate in the normal HDL-C group were lower than those in the low HDL-C group by 40% and 53% respectively. The AMI event rate and CHD death rate in the high HDL-C group were lower than those in the normal HDL-C gr

关 键 词：高密度脂蛋白 老年人 冠心病 保护作用 急性心肌梗死 

分 类 号：R541.4[医药卫生—心血管疾病]