PLA-PEG共聚物三维多孔支架的制备及表征  

Preparation and Characterization of Three-Dimensional Porous Scaffolds of PLA-PEG Copolymer

作　　者：任杰[1] 吴志刚[1] 贾晓真[2] 张乃文[1] 

机构地区：[1]同济大学材料科学与工程学院纳米与生物高分子材料研究所,上海200092 [2]同济大学口腔医学院,上海200092

出　　处：《材料导报》2004年第3期93-95,共3页Materials Reports

基　　金：上海市科技发展基金重点基础研究项目(02DJ14061);上海市社会发展基金(002312024)

摘　　要：将D,L-丙交酯(D,L-LA)与聚乙二醇(PEG)共聚制备了一系列共聚物,并用IR、GPC和1H-NMR对其进行了表征.在此基础上,采用溶剂浇铸-柱子沥滤技术和层叠技术制备了具有一定空间形状的三维多孔组织工程支架,并研究了致孔剂颗粒尺寸及其用量对多孔支架的孔径、孔隙率的影响.结果表明,PLA-PEG共聚物的分子量随着原料中PEG含量的增加而减小;以PLA-PEG共聚物为原料制备多孔支架时,孔径的大小与致孔剂颗粒尺寸有一定的对应关系,孔隙率随着致孔剂用量的增加而增加;采用层叠技术制备的具有一定形状的三维多孔支架符合组织工程对支架材料的一般要求.In this study, a series of copolymers were synthesized with D,L-LA and PEG and were characterized by IR,GPC and ~1H-NMR. 3-D porous tissue engineering scaffolds were prepared by solvent-casting/particleleaching technique and lamination technique. Afterwards, the relationships of the average pore diameter and the porogen particle size, the porosity and the porogen weight fraction was established. The result indicates that the molecular weight of PLA-PEG copolymer depends on the ratio of D,L-LA to PEG. It was found that the porosity of porous scaffolds and the average pore diameter increased with porogen weight fraction and porogen particle size respectively , and 3-D porous scaffolds prepared with lamination technique were in compliance with the requirements of tissue engineering for scaffolds.

关 键 词：PLA-PEG共聚物 三维多孔支架 制备工艺 溶剂浇铸-粒子沥滤技术 层叠技术 生物材料 

分 类 号：R318.08[医药卫生—生物医学工程]