对益舒欣软胶囊活血化瘀、改善微循环作用的研究  

EXPERIMENTAL STUDY ON THE EFFECTS OF "YI SHU XIN SOFT CAPSULE" ON HEMORHEOLOGY AND INPROVING MICROCIRCULATION

作　　者：王瑜[1] 李鹏[2] 邓秀玲[1] 孙晓东[1] 袁秉祥[1] 于小江[1] 

机构地区：[1]西安交通大学医学院,陕西西安710061 [2]武警贵州总队医院,贵州贵阳550005

出　　处：《甘肃中医》2004年第3期36-39,共4页Gansu Journal of Traditional Chinese Medicine

摘　　要：目的:探讨益舒欣软胶囊作用机制。方法:以血小板最大聚集率,环状动静脉血栓湿重,血栓形成抑制率,肠细膜毛细血管管径和毛细血管流速,血液黏度和纤维蛋白原含量等为指标,观察其活血化瘀、改善微循环的作用。结果:益舒欣大剂量组可显著抑制家兔血栓形成,减轻血栓湿重,还可显著降低家兔血小板最大聚集率,对于大鼠肠细膜毛细血管管径和毛细血管流速均可显著性增加,还可显著降低模型大鼠的纤维蛋白原含量和血浆黏度。同时基质葵花籽油亦有辅助功能。结论:益舒欣软胶囊具有溶血栓、抑制血小板凝集、改善微循环的作用。Yi Shu Xin soft capsule' mainly composed of Ginkgo biloba flavone is Chinese traditional medicine preparation.In order to observe its effect on hemorheology and improving microcirculation,we adopted such following target parameters as the maximum platelet aggregation rate (MPAR),wet weight of thrombus,inhibitory rate of thrombosis,semidiameter of mesentery capillary and volume of blood flow,plasma fibrinogen levels and blood and plasma viscosity,etc. Result:A large dose of 'Yi Shu Xin' inhibit the form of thrombus in rabbit remarkable, to lose the wet weight of thrombus and to reduce rabbit MPAR significantly. Both semidiameter of rat mesentery capillary and volume of blood flow were found to be higher in total 'Yi Shu Xin' groups. Plasma fibrinogen levels and blood viscosity(including plasma viscosity) of rat's blood stasis model is lower than that before using larger dose drug.Plasma viscosity and plasma fibrinogen levels were comparable.Sunflowerseed salad oil,as a dissolving agent of drug,also has assistant function to reduce Blood Viscosity.All of these proved 'Yi Shu Xin soft capsule' could dissolve thrombus,inhibit platelet adhesion reaction and improve microcirculation.The doctor who uses the drug will benefit from the date in research.

关 键 词：益舒欣软胶囊 银杏黄酮甙 血小板聚集 血栓形成 血浆黏度 微循环 血液流变学 

分 类 号：R2-03[医药卫生—中医学]