GABA抑制hCG诱发大鼠卵巢黄体细胞孕酮生成  

GABA inhibits progesterone production induced by hCG in luteal cells of rat ovary

作　　者：张辉[1] 张玮[1] 倪江[1] 田淑君[1] 边淑玲[1] 张丽敏[1] 

机构地区：[1]哈尔滨医科大学生理教研室,哈尔滨150086

出　　处：《基础医学与临床》2004年第1期40-43,共4页Basic and Clinical Medicine

基　　金：黑龙江省教委资助课题 ( 10 5 110 5 7)

摘　　要：观察了中枢抑制性神经递质γ 氨基丁酸 (GABA)对人绒毛膜促性腺激素 (hCG)诱发大鼠卵巢黄体细胞孕酮的生成 ,及对羟自由基 (·OH)产生的影响。结果显示 :GABA抑制基础及hCG诱发黄体细胞孕酮的生成 ,同时发现黄体细胞羟自由基的生成增多。表明 :GABA抑制孕酮的生成可能与自由基有关 ,并可能通过cAMP PKA系统发挥作用 。To investigate the effect of GABA on progesterone production induced by hCG and hydroxyl radical level in luteal cells of rat ovary. The present study shows that GABA inhibits progesterone secretion and increases the amount of hydroxyl radical in cultured rat luteal cells. The inhibitory effect of GABA on progesterone production may be related to free radical and be mediated by cAMP-PKA system, which is different from the mechanism mediating the effect of GABA on central nervous system.

关 键 词：GABA HCG 大鼠 卵巢 黄体细胞 孕酮 γ-氨基丁酸 中枢抑制性神经递质 人绒毛膜促性腺激素 

分 类 号：R33[医药卫生—人体生理学]