加减地黄饮子对Aβ-40所致痴呆大鼠学习记忆、脑酶活性的影响  

Study on the effect of modified decoction of rehmanniae on behavioral and mda activities in model rats of senile dementia which was led by β-AMYLOID

作　　者：谢宁[1] 牛英才[1] 宋琳[1] 邹纯朴[1] 

机构地区：[1]黑龙江中医药大学,黑龙江哈尔滨150040

出　　处：《中医药信息》2004年第2期57-58,共2页Information on Traditional Chinese Medicine

基　　金：黑龙江省自然科学基金资助项目 (D0 0 2 8)

摘　　要：用大鼠海马注射β淀粉样蛋白诱导的老年性痴呆模型 ,并以正常老龄鼠为空白对照 ,西药脑复康为阳性对照 ,对加减地黄饮子预防组和治疗组从行为学、单胺氧化酶 (MDA)改变等方面进行了初步的实验观察 ,以探讨加减地黄饮子对Aβ - 40所致痴呆大鼠学习记忆及MDA活性影响。实验证明造模大鼠较好地模拟了老年性痴呆行为学表现和MDA改变 ;加减地黄饮子可改善老年性痴呆大鼠行为学功能 ,并能降低单胺氧化酶的活性.This experiment take rats of which β-amyloid was injected into the hippocampus as the model animals,aging rats as blank control group and the model taking piracetam as positive control group.The preventive and curing functions of the Modified Decoction of Rehmanniae were synthetically studied on behavior and MDA.The laboratory prove that the model rats better imitate behavior changing and MDA changing of AD,Modified Decoction of Rehmanniae prescriptions had such functions compared with the model group that Improving behavior function of AD rat and Dropping the activity of AMO. Author's address:Heilongjiang University of Traditional Chinese Medicine,Harbin 150040,China

关 键 词：ALZHEIMER氏病 加减地黄饮子 Aβ-40 行为学 实验研究 

分 类 号：R285.5[医药卫生—中药学]