固本止咳胶囊醇提取制备工艺的研究  

Study on Preparation Process of Alcohol Extracting of Gubenzhike Capsules

作　　者：蔡晓[1] 余英[1] 李富贵[1] 

机构地区：[1]四川省劳动卫生职业病防治研究所,四川成都610041

出　　处：《中国药业》2004年第3期58-59,共2页China Pharmaceuticals

摘　　要：目的:优选固本止咳胶囊的醇提工艺。方法:采用正交试验法对乙醇浓度、乙醇用量、提取时间、提取次数4个主要因素选取3个水平,以芍药苷为指标成分,应用高效液相色谱法进行定量分析。结果:最佳工艺为加药材8倍量和6倍量70%乙醇,回流提取2次,时间为1.5h和1h。结论:该最佳工艺能保证固本止咳胶囊的质量。Objective: To optimize the alcohol extraction process of Gubenzhike capsules. Methods:The optimum extraction process was investigated by orthogonal design. The chief factors influencing the extraction efficiency were as follows(A: alcohol concentration, B: alcohol amount, C: times of extraction, D: number of extracting).The paeoniflorin in the liguaid of extraction as an index, the content was determined by HPLC. Results:The optimum extracting condition was adding eight and six times amount of 70% alcohol and refluxing extracting for 1. 5 h and 1 h(totally extracting for two times).Conclusion: The quality of the capsules was pledged by this optimized process.

关 键 词：固本止咳胶囊 芍药苷 正交试验 提取工艺 

分 类 号：R944.5[医药卫生—药剂学] TQ461[医药卫生—药学]