鹿茸口服液对小鼠实验性肝损伤的保护作用  

Protective effect of pilose antler oral liquid (PAOL) on experimental liver injuries

作　　者：祁雪[1] 刘秀梅[2] 陈晓光[2] 

机构地区：[1]吉林省人民医院药剂科,长春130031 [2]吉林省中医中药研究院药理室,长春130021

出　　处：《中药药理与临床》2004年第1期42-43,共2页Pharmacology and Clinics of Chinese Materia Medica

摘　　要：目的 :研究鹿茸口服液对小鼠实验性肝损伤的保护作用。方法 :采用四氯化碳 (CCl4)、D 半乳糖胺 (D Gla)、硫代乙酰胺 (TAA)和扑热息痛 (AAP)致小鼠急性肝损伤模型 ,测定小鼠血清SGPT活性 ,肝组织DNA、RNA、蛋白质、糖原含量。结果 :鹿茸口服液可明显降低上述急性肝损伤模型小鼠血清SGPT活性、增加CCl4肝损伤模型小鼠肝组织RNA、蛋白质、糖原含量。结论 :鹿茸口服液对小鼠实验性肝损伤具有保肝作用。Objective: To investigate the protective effect of PAOL on experimental liver injuries. Methods: The activity of serum SGPT and the contents of liver DNA, RNA, protein, glycogen were measured in the model mice of liver injury induced by carbon tetrachloride (CCl 4), D-galactosamine (D-Gla), Acetaminophen (AAP) and Thioacetamide (TAA). Results: The serum SGPT activity was significantly lowered in the model mice of liver injury induced by CCl 4, D-Gla, AAP and TAA, and the contents of liver RNA, protein, glycogen were increased obviously in the model mice of liver injury induced by CCl 4 after PAOL was given orally. Conclusion: PAOL exhibited protective effect on experimental live injuries.

关 键 词：鹿茸口服液 小鼠 实验性肝损伤 保护作用 中药 

分 类 号：R285[医药卫生—中药学]