Synthesis of 1-Bromo-3-methoxy-4-propoxy-5-iodobenzene——A Novel Efficient Process for the Synthesis of Brominated Aromatic Compound  

作　　者：HongXinSHI HuiLIN GérardMANDVILLE 

机构地区：[1]ZhejiangKeyLab.ofGreen-chemicalSyntheticTechnology,ZhejiangUniversityofTechnology,Hangzhou310014 [2]DepartmentofChemistry,InstituteofScience,ZhejiangUniversity,Hangzhou310012 [3]UniversitédeParis-Sud,ICMO,91405OrsayCédexFrance

出　　处：《Chinese Chemical Letters》2004年第3期288-291,共4页中国化学快报（英文版）

摘　　要：The reaction of aromatic carboxylic acid with oxalyl chloride gives rise to the corres- ponding acid chloride which without purification is treated with the sodium salt of mercapto- pyridine oxide in the presence of 2,2-azo-bisisobutyronitrile (AIBN), radical initiator to give a brominated aromatic compound. After etherification and oxidation, 5-iodovaniline was converted to trisubstituted benzene carboxylic acid which give 1-bromo-3-methoxy-4-propoxy-5-iodo- benzene by this new brominating process with a yield of 74 %.The reaction of aromatic carboxylic acid with oxalyl chloride gives rise to the corres- ponding acid chloride which without purification is treated with the sodium salt of mercapto- pyridine oxide in the presence of 2,2-azo-bisisobutyronitrile (AIBN), radical initiator to give a brominated aromatic compound. After etherification and oxidation, 5-iodovaniline was converted to trisubstituted benzene carboxylic acid which give 1-bromo-3-methoxy-4-propoxy-5-iodo- benzene by this new brominating process with a yield of 74 %.

关 键 词：Synthesis radical substitution 1-bromo-3-methoxy-4-propoxy-5-idiobenzene bromi- nation. 

分 类 号：O625.2[理学—有机化学]