合并骨质疏松的自身免疫性甲状腺炎女性患者降钙素储备功能测定  

Determination of calcitonin reserve function in female autoimmune thyroiditis patients complicated with osteoporosis

作　　者：李子玲[1] 张士明[2] 黎云燕[2] 王艳萍[2] 马伯海[3] 张煜[3] 

机构地区：[1]内蒙古医学院第三附属医院内分泌科,包头014010 [2]天津医科大学第二医院 [3]天津医科大学津城放免中心

出　　处：《中华内分泌代谢杂志》2003年第2期89-91,共3页Chinese Journal of Endocrinology and Metabolism

摘　　要：目的　探讨降钙素 (CT)在女性自身免疫性甲状腺炎 (AIT)患者骨质疏松 (OP)发病中的作用。方法　对 2 5例健康女性对照者及 3 3例女性AIT患者 ,其中无OP者 16例 ,合并OP者 17例 ,用钙负荷 CT兴奋试验分别观察各组CT基础值及其储备功能的改变。结果　 (1)AIT患者CT基础值及其储备功能均低于对照组 (P <0 .0 5 )。 (2 )合并OP的AIT患者CT基础值及其储备功能比无OP的AIT患者更低 (P <0 .0 5 )。结论　在合并OP的女性AIT患者中 ,CT缺乏可能参与OP发生机制。Objective To study the role of calcitonin (CT) in female autoimmune thyroiditis (AIT) patients complicated with osteoporosis (OP). Methods The calcium load-CT stimulation test was performed in 25 healthy female controls, and 33 female patients with AIT including 16 cases without OP and 17 cases with OP, and the basal value and reserve function of CT in these two groups were observed. Results (1) The basal and peak concentrations ofCTaftercalciumloadwerelower in the patients with AIT than those in normal controls (P<0.05). (2) The basal and peak concentrations of CT after calcium load in patients of AIT with OP were lower than those in patients of AIT without OP (P<0.05). Conclusion In female AIT patients with OP, CT deficiency seems to participate in the pathogenesis of OP.

关 键 词：合并症 骨质疏松 自身免疫性甲状腺炎 女性 降钙素 储备功能 测定 

分 类 号：R581.4[医药卫生—内分泌] R681[医药卫生—内科学]