抗氧化维生素降低2型糖尿病患者血清可溶性血管细胞粘附分子1水平  

Antioxidative vitamins reduce serum level of soluble vascular cell adhesion molecules-1 in type 2 diabetes

作　　者：徐茂锦[1] 邹大进[1] 叶江洪[2] 冯正康[1] 张小瑛[3] 

机构地区：[1]第二军医大学附属长海医院内分泌科,上海200433 [2]解放军411医院内一科 [3]第二军医大学附属长海医院肾内科,上海200433

出　　处：《中华内分泌代谢杂志》2003年第2期119-121,共3页Chinese Journal of Endocrinology and Metabolism

摘　　要：目的　研究补充大剂量维生素C、维生素E对 2型糖尿病患者血清可溶性血管细胞粘附分子(sVCAM) 1水平的影响。方法　用ELISA法测定 2型糖尿病患者补充维生素前后血清sVCAM 1水平并分析其与肿瘤坏死因子α(TNF α)、内皮素 (ET)、HbA1c、空腹血糖、甘油三酯、胆固醇、胰岛素 (IRI)的关系。结果　 2型糖尿病患者补充大剂量维生素C、维生素E后sVCAM 1、TNF α、ET水平下降 ,联合服用组下降更明显 ;sVCAM 1与TNF α、ET及HbA1c呈正相关。结论　大剂量维生素C、维生素E能够降低 2型糖尿病患者血清sVCAM 1的水平并具有协同作用 ,其机制可能与维生素C、维生素E的抗氧化、抗糖化作用致HbA1c生成减少、TNF α、ET水平减低有关。Objective To study the effect of high vitamin C and vitamin E intake on serum level of soluble vascular cell adhesion molecules (sVCAM)-1 in type 2 diabetic patients. Methods Serum level of sVCAM-1 was measured by ELISA before and after vitamin supplement in 60 patients with type 2 diabetes. The correlations between sVCAM-1 and tumor necrosis factor (TNF)-α, endothelin (ET), HbA 1c , fasting blood glucose, triglyceride, total cholesterol, immunoreactive insulin were determined respectively, and 20 patients served as controls. Results Serum level of sVCAM-1 decreased after high vitamin C and vitamin E intake, especially in the combined vitamins group; there were positive correlations between sVCAM-1 and TNF-α, ET, HbA 1c respectively. Conclusion High vitamin C and vitamin E intake can decrease the serum level of sVCAM-1 in type 2 diabetic patients and show synergistic action, the mechanism is probably due to their antioxidation and antiglycosylation, resulting in lowered levels of HbA 1c , TNFα and ET.

关 键 词：抗氧化 2型糖尿病 血清 可溶性血管细胞粘附分子1 大剂量 维生素C 维生素E 

分 类 号：R587.1[医药卫生—内分泌] R977.2[医药卫生—内科学]