重庆市人群的微量白蛋白尿与代谢综合征的关系调查  

A survey on the association of microalbuminuria with metabolic syndrome in the population of Chongqing

作　　者：杜娟[1] 张素华[1] 任伟[1] 包柄楠[1] 王继旺[1] 陈静[1] 何军[1] 粟绍初[1] 

机构地区：[1]重庆医科大学附属第一医院内分泌科,400016

出　　处：《中华内分泌代谢杂志》2003年第6期439-441,共3页Chinese Journal of Endocrinology and Metabolism

摘　　要：目的　探讨微量白蛋白尿 (MAU )与代谢综合征 (MS)的相关性。方法　在重庆市城市职工健康体检人群中随机抽取 3 0岁以上者 45 7例 ,按美国国家胆固醇教育计划 (NCEP ATPⅢ ,2 0 0 1)提出的MS最新诊断标准 ,分为正常对照组 (NC组 )、MS单项异常组 (MS1组 )、不完全MS组 (MS2组 )和完全MS组 (MS3组 )。用化学发光法检测尿微量白蛋白 ,并与相关指标进行多元回归分析。结果　本组人群中完全MS的患病率为 17.5 %。MS2组和MS3组HOMA IR均高于NC组 ,差异有显著性 (均P <0 .0 5 ) ,且年龄偏高 ,男性多于女性。MS3组伴有MAU者占 18.8% ,明显高于其它组 ;MS3组尿微量白蛋白排泄率(UAER)高于NC组 (P <0 .0 5 )。且MS3组UAER与收缩压、餐后 2h血糖呈正相关。结论　NCEP ATPⅢ (2 0 0 1)中MS的诊断标准亦适用于中国人群 ,MAU是MS的关联因素。Objective To investigate the relationship between microalbuminuria (MAU) and metabolic syndrome (MS). Methods Four hundred and fifty-seven subjects aged over 30 years were randomly selected from the population for health examination. According to the latest diagnostic standard of National Cholesterol Education Program (NCEP)-ATPⅢ (2001), the subjects were divided into 4 groups: control group (group NC) (n=149), only one abnormal item group (group MS1) (n=136), incomplete MS group (group MS2) (n=92) and complete MS group (group MS3) (n=80). MAU was assayed in each group by chemiiluminescence method and multiple regression analysis of MS was performed in MAU and other relative parameters. Results The prevalence of complete MS in the present study was 17.5%. HOMA-IR either in group MS2 or in group MS3 was higher than that in group NC (both P<0.05). Subjects in group MS2 and group MS3 were older than those in group NC and predominant in males. The incidence of MAU in group MS3 was 18.8%, higher than those in the other groups. UAER in group MS3 was higher than that in group NC (P<0.05). The MAU in group MS3 showed positive correlation with systolic blood pressure and 2 hour postprandial plasma glucose. Conclusion The diagnostic standard of NCEP-ATPⅢ (2001) is also applicable for Chinese population. MAU is a factor related to MS.

关 键 词：重庆市人群 微量白蛋白尿 代谢综合征 调查 相关性 化学发光法 检测 

分 类 号：R58[医药卫生—内分泌]