白细胞介素-1α、4、6基因多态性与Graves病的关系  

Association of interleukin-1α,4,6 gene polymorphisms with Graves' disease

作　　者：龚莹[1] 蒋玲[1] 江维岩[2] 张晓黎[1] 赖宏[1] 武传龙[1] 

机构地区：[1]山东大学齐鲁医院内分泌科,济南250012 [2]泰安市中心医院

出　　处：《中华内分泌代谢杂志》2003年第6期459-460,共2页Chinese Journal of Endocrinology and Metabolism

基　　金：山东省卫生厅项目 (2 0 0 1CAICJB1 0 )

摘　　要：本研究分析了中国山东地区汉族人群Graves病患者与健康对照者白细胞介素 1α、4、6基因多态性。结果表明Graves病患者白细胞介素 4(-5 90 )c/t基因型和t等位基因频率均低于健康对照组。Interleukin (IL)-1α, 4, 6 gene polymorphisms were analysed in patients with Graves′ disease (GD) and controls of Han population in Shandong province. The results showed that frequencies of IL-4 (-590) c/t genotype and t allele were significantly lower in patients with GD than those in controls.

关 键 词：白细胞介素-1Α 白细胞介素-4 白细胞介素-6 基因多态性 GRAVES病 等位基因 基因频率 甲状腺功能亢进 

分 类 号：R581.1[医药卫生—内分泌] R394[医药卫生—内科学]