抗生素对宿主体内微生态平衡影响的数学模型研究  

Mathematical model of the effect of antibiotics on micro-ecosystem in the host

作　　者：王开发[1] 邱志鹏[2] 樊爱军[1] 刘俊康[3] 袁泽涛[3] 邓国宏[4] 

机构地区：[1]第三军医大学基础医学部数学教研室,重庆400038 [2]南京理工大学应用数学系,南京210094 [3]第三军医大学科研部生物波研究中心 [4]第三军医大学附属西南医院全军感染病研究所,重庆400038

出　　处：《第三军医大学学报》2003年第15期1368-1372,共5页Journal of Third Military Medical University

基　　金：国家自然科学基金资助项目 ( 10 10 10 2 9)

摘　　要：目的　探讨抗生素对宿主体内菌群的影响。方法　应用微分方程定性理论分析抗生素作用的两菌群数学模型。结果　宿主体内微生态系统的平衡与失调与抗生素的输入浓度和各菌群的初始值有关。结论　临床上运用抗生素去治疗细菌感染性疾病时 ,必须十分注意抗生素的输入浓度和相关菌群的初始值 ,否则将可能会引起新的急性菌群失调。Objective To explore the effect of antibiotics on florae in the host. Methods Qualitative Theory of Ordinary Differential Equation was employed to analyze the mathematical model of two florae under the effect of antibiotics. Results The introduced concentration of the antibiotics and the initial value of bacteria were correlated with balance and imbalance of microecosystem. Conclusion Attention must be paid to the introduced concentration of antibiotics and the initial value of correlative bacteria in clinical treatment of bacterial infection related diseases to avoid leading to new acute flora imbalance.

关 键 词：抗生素 栖生 感染 细菌平衡 菌群失调 

分 类 号：R311[医药卫生—基础医学] R37