肿瘤坏死因子-α和充血性心力衰竭  

Tumor Necrosis Factor-α and Congestive Heart Failure

作　　者：陈齐红[1] 覃数[1] 

机构地区：[1]重庆医科大学附属第一医院心内科，重庆400016

出　　处：《心血管病学进展》2004年第2期89-91,共3页Advances in Cardiovascular Diseases

摘　　要：肿瘤坏死因子 α(TNF α)是一种具有多种生物学效应的细胞因子 ,它抑制心肌收缩性 ,诱导心肌细胞凋亡 ,促进心肌重构 ,在左室功能紊乱和充血性心力衰竭 (CHF)发病机制中起重要作用。虽然最近完成的两个大规模的临床实验 (RENEWAL和ATTACH)发现TNF α拮抗剂治疗CHF不能令人满意 ,但它只是抑制TNF α作用的一个环节 ,针对CHF的抗TNF α治疗有待于进一步评价。TNF-α,a kind of cytokine with many biological ef fe cts,plays an important role in congestive heart failure pathogenesis,it depresse s myocardial contractility,induces myocardial apoptosis,promotes myocardial remo delling.Although the results of two clinical trial programmes ( RENEWAL and ATTA CH ) newly finished are disappointing,the drugs used in the tests only antagonis m part of TNF-α.Studies of anti-TNF-α therapy to CHF are still in progress which need further evaluation.

关 键 词：肿瘤坏死因子-Α 充血性心力衰竭 生物学效应 发病机制 

分 类 号：R541.6[医药卫生—心血管疾病]