同型半胱氨酸与血管成形术后新内膜增生的研究进展  

The Progress of Study in Homocysteine and Neointimal Hyperplasia After Angioplasty

作　　者：徐会圃[1] 冯义柏[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院心内科，湖北武汉430022

出　　处：《心血管病学进展》2004年第2期128-131,共4页Advances in Cardiovascular Diseases

摘　　要：同型半胱氨酸是一种含硫的非必需氨基酸 ,其在血管动脉粥样硬化中的作用已得到大量资料证实。近来发现其有促进血管成形术后血管内膜增生的作用 ,从而促进血管再狭窄。高同型半胱氨酸不仅具有抑制血管内皮损伤后内皮修复的作用 ,而且有促进内皮下血管平滑肌细胞增殖及迁移的作用 ,这可能是其促进血管成形术后新内膜增生的机制。Homocysteine(HCy),a sulphur-containing non-esse nt ial amino acid,has been confirmed that there is a important role in the pathophy siology of atherosclerosis.Recently,the non-essential amino acid has been found that there is a role on the neointima hyperplasia angioplasty restenosis.Hyperh omocysteine is able to inhibit the proliferation of the endothelial cell at the same time as stimiulating the vascular smooth muscle cells proliferation and mig ration,this may be mechanism of neointimal hyperplasia induced by homocysteine a fter angioplasty.

关 键 词：同型半胱氨酸 血管成形术 术后 冠心病 新内膜增生 高同型半胱氨酸血症 

分 类 号：R654.2[医药卫生—外科学]