5-取代-1H-1,2,4-三氮唑-3-羧酸的合成及结构表征  

The Synthesis of 5-Substituting group-1H-1,2,4-Triazole-3-Carboxylic Acid Ethyl Ester

作　　者：李德江[1,2] 孙碧海[1,2] 李斌 

机构地区：[1]湖北省丹江口市郧阳师范专科学校化学系,湖北丹江口市442700 [2]武汉化工学院制药工程系,湖北武汉430073

出　　处：《精细化工中间体》2004年第1期35-37,共3页Fine Chemical Intermediates

摘　　要：以5 氯基 1H 1,2,4 三氮唑 3 羧酸乙酯为原料,经Sandmeyer反应合成了5 取代 1H 1,2,4 三氮唑 3 羧酸乙酯,其中取代基为氯、溴、碘、氰基等。并通过UV,IR,1HNMR和元素分析对所有产物的结构进行了表征。1H-1,2,4-triazole derivatives,owing to their extensive uses in pharmaceutical synthesis,in an effort to search for more useful reaction intermediates containing 1H-1,2,4-triazole, four new 5-substituted-1H-1,2,4-triazoles were synthesized from 5-amino-1H-1,2,4-triazole-3-carboxylic acid ethyl ester by Sandmeyer reaction. Their structures were confirmed by elementl analysis, IR, UV and ~1 HNM.

关 键 词：5-氨基-1H-1 2 4-三氮唑-3-羧酸乙酯 Sandmeyer反应 合成 表征 

分 类 号：TQ252.6[化学工程—有机化工]