痴呆康对血管性痴呆大鼠脑组织中内皮素和降钙素的调节作用  

Effect of Chidaikang on the levels of ET-1 and CGRP of brain tissue in vascular dementia rats

作　　者：龚振岭 李兴琴[2] 龚志刚 靳同春 杨建忠 

机构地区：[1]河北省正定县中医研究所附院,河北正定050800 [2]河北省医科院,河北石家庄050000 [3]河北省正定县人民医院,河北正定050800 [4]河北省正定县中医院,河北正定050800

出　　处：《河北医学》2004年第2期116-118,共3页Hebei Medicine

摘　　要：目的 :通过对VD大鼠脑组织ET - 1和CGRP含量的测定 ,探讨其在VD形成过程中的发病机制和中药干预机制。方法 :采用放射免疫分析法测定脑组织ET - 1和CGRP浓度。结果 :①模型对照组与正常对照组比较 ,ET - 1含量升高 ,CGRP含量降低 ,均有极显著差异 (P <0 .0 1) ;②与模型组比较 ,中剂量和大剂量组ET - 1含量较治疗前明显降低 (P <0 .0 1,P <0 .0 5 ) ,CGRP含量较治疗前明显升高 (P <0 .0 1,P <0 .0 5 )。结论 :中药能有效调节二者的平衡 ,是防治VD的可能机制之一。Objective: To explore the mechanism of Chi Dai Kang on the levels of ET-1 and CGRP of brain tissue in vascular dementia rats. Method: The levels of endothelin-1 and calcitionin gene related peptide were measured by radiommunoassay. Results:①The model group compared with the control,ET-1 level increase and CGRP level decreased markedly.②The therapeutic group can reduce the release of ET-1 and increase the level of CGRP. Conclusion: Chi Dai Kang can balance their levels,which is one of the mechanisms to treat vascular dementia.

关 键 词：痴呆康 血管性痴呆 内皮素 降钙素基因相关肽 

分 类 号：R285[医药卫生—中药学]