医用聚氯乙烯的表面磺酸化及抗凝血性能研究  

Surface sulphonate and antithrombogenicity of medical poly(vinyl chloride)

作　　者：刘鹏[1] 陈亚芍[1] 万秀琴[1] 张丽惠[1] 

机构地区：[1]陕西师范大学化学与材料科学学院,陕西西安710062

出　　处：《陕西师范大学学报（自然科学版）》2004年第1期73-76,共4页Journal of Shaanxi Normal University：Natural Science Edition

基　　金：陕西省自然科学基金资助项目(2001H18);教育部留学回国人员科研启动基金资助项目(2001345)

摘　　要：利用SO2/O2混合气体等离子体处理医用聚氯乙烯(PVC)膜,在材料表面引入磺酸基,借助X射线光电子能谱和ATR FTIR光谱对膜表面的组成及结构进行表征,通过动态凝血实验以及凝血酶原时间、部分凝血活酶时间、凝血酶时间的测定,对聚氯乙烯膜的抗凝血性能进行评价.实验结果表明,等离子体处理聚氯乙烯膜可以在材料表面有效地引入磺酸基,显著提高材料的抗凝血性能.In order to introduce sulphonic group on the surface of medical poly(vinyl chloride)(PVC) film,the film is treated by SO_2/O_2 mixture gas plasma. Surface composition and structure of PVC film is characterized with XPS and FT-IR spectroscopy. The antithrombogenicity of PVC film is accessed by the dynamic blood-clotting test and determined by the method of the prothrombin time,the activated partial thomboplastin time and the thrombin time test. The results showed that sulfonic group is effectively introduced on the surface of PVC film and the antithrombogenicity of the film is remarkably increased.

关 键 词：聚氯乙烯膜 等离子体 抗凝血性能 表面磺酸化 医用高分子材料 

分 类 号：R318.08[医药卫生—生物医学工程] TQ325.3[医药卫生—基础医学]