米索前列醇用于足月妊娠引产对新生儿的安全性研究  

Safety of neonate in misoprostol induced labor for full-term pregnancy

作　　者：周玉玲[1] 李世兰[1] 李罗珍[1] 王玉华[1] 王雷[1] 华川[1] 

机构地区：[1]解放军252医院,河北保定071000

出　　处：《华北国防医药》2003年第6期397-399,共3页Medical Journal of Beijing Military Region

摘　　要：目的探讨米索前列醇(简称米索)用于足月妊娠引产对胎儿的近期安全性。方法 将106例足月妊娠初产妇分为两组,分别以米索50μg、25μg放置于阴道后穹隆,每3小时1次,直至临产停药,每日用药以4次为限。选择同期住院,自然临产的初产妇56例作为对照组。用放射免疫测定法测定三组新生儿出生后第1次呼吸建立之前脐静脉血血浆中内皮素-1和心钠素水平,并对10例50μg米索引产、10例自然临产,经阴道分娩的足月妊娠初产妇的胎盘进行透射电镜观察。结果①两试验组间引产成功率及三组间分娩方式、羊水粪染及胎儿窘迫发生率、新生儿出生后评分及新生儿体重均元显著的统计学差异(P>0.05)。②三组间脐静脉血内皮素和心钠素水平无统计学差异。③胎盘合体滋养细胞、细胞滋养细胞、绒毛毛细血管内皮细胞的超微结构在实验组及对照组之间未发现明显不同。结论 米索用于足月妊娠引产对胎儿及新生儿是安全的。Objective To approach the short-term security of newborn in misoprostol induced labor for full-term pregnancy . Methods 106 primiparas at term pregnancy with inclusion criteria were divided randomly into two groups. 56 subjects in one group and 50 subjects in the other received the misoprostol 50 μg,25 μg vaginally every 3 hours respectively,all subjects received the drug constantly till the onset of labor and the most frequency was 4 times per day. 56 primiparas with onset of natural labor hospitalized in same period served as controls. Before the first breath of neonate, umbilical vein blood were taken and the levels of ET-1 and ANP of umbilical vein plasma were determined with RIA. The specimens of placenta from 10 women in induced labor with 50 μg misoprostol and 10 women in natural delivery were examined with electron microscopy. Results ⅠThere were no statistical differences in the success rate of labor induction between the two study groups; among the three groups there were no statistical differences in the following aspects: way of parturition, the incidence of amniotic fluid contamination with meconium and the fetal distress, the neonatal Apgar score and the neonatal weight (P > 0. 05). ⅡThe differences of the levels of ET-1 and ANP of umbilical vein plasma among the three groups were not statistically significant. ⅢNo significant differences were observed with electron microscopy in trophoblastic cell and villi capillary vessels of placenta between the misoprostol group and the control group. Conclusions It was found safe to the neonate to administrate 50 μg or 25 μg misoprostol vaginally every 3 hours in induced labor for the full-term pregnancy.

关 键 词：米索前列醇 足月妊娠 引产术 新生儿 胎儿 ET 心钠素 内皮素 ANP 

分 类 号：R719.31[医药卫生—妇产科学]