“糖脂消”对代谢综合征的疗效研究  

Effectiveness of Tang Zhi Xiao in treatment of patients with metabolism syndrome

作　　者：侯振民[1] 李玉明[1] 李振有[1] 周玲玲[1] 

机构地区：[1]武警医学院附属医院,天津300162

出　　处：《武警医学》2004年第1期15-18,共4页Medical Journal of the Chinese People's Armed Police Force

摘　　要：目的　观察“糖脂消”对代谢综合征的临床疗效 ,探讨其作用机制。方法　入选本研究的 112例患者中 ,共有 86例患者完成研究 ,其中男 48例 ,女 3 8例。糖尿病治疗组 2 1例 ,口服“糖脂消”胶囊 8粒 ,3 /d ;对照组 2 3例 ,口服格列齐特片(Ⅱ ) 80mg ,2 /d。血脂异常治疗组 2 2例 ,口服“糖脂消”胶囊 (剂量、方法同上 ) ;对照组 2 0例 ,口服藻酸双脂钠 0 1g ,3 /d。结果　 (1)“糖脂消”改善乏力、头晕等症状明显优于对照组 (P <0 0 5) ;(2 )“糖脂消”明显降低空腹血糖 (FPG) ,由 (8 3 0± 0 .3 2 )mmol/L降至 (6 12± 0 .3 0 )mmol/L ,空腹胰岛素 (FINS)由 (49 3± 2 .5)mU/L降至 (3 4 4± 2 0 )mU/L ,改善胰岛素敏感指数 (ISI)由 (-6.68± 0 .3 1)升至 (-5.0 7± 0 .2 9) (P <0 0 1) ,并显著好于对照组 (P <0 0 5) ;(3 )“糖脂消”的调脂作用 :总胆固醇 (TC)、甘油三酯 (TG)及低密度脂蛋白胆固醇 (LDL -C)明显降低 ,分别由 (6 88± 0 .54)mmol/L ,(2 85± 0 3 1)mmol/L和 (4 12± 0 .2 5)mmol/L降至 (5 82± 0 48)mmol/L ,(2 .0 1± 0 .2 8)mmol/L和 (3 .0 5± 0 .3 5)mmol/L ,升高高密度脂蛋白胆固醇 (HDL -C)水平由(1.3 8± 0 .3 2 )mmol/L升至 (1 78± 0 .3 1)mmol/L。结论　“糖脂消”有?Objective To evaluate the clinical efficacy of Tang Zhi Xia o against metabolism syndrome .Methods Eighty-six patients with metabolism syndrome,including 48 males and 38 females,w ere enrolled in this study.They were divided into four groups:21 patients ,with diabetes mellitus were given 8 capsules of Tang Zhi Xiao three times daily ;the other 23 diabetic patients received 80 mg of Gliclazide tablet,two times da ily for comparison.Patients with hyperlipemia were given Tang Zhi Xiao 8 capsul es three times daily,while the other 20 patients with hypezlipemia received 100 mg of alginic sodium diester tablet three times daily for comparison.Res ults (1)Tang Zhi Xiao capsule alleviated clinical symptoms (P<0.05 ).(2)It effectively decreased fashing plasma glucose (FPG) level from(8.30±0.32 ) to(6.12±0.30) mmol/L and fasting insulin (FINS) level from(49.3±2.5) to (34.4 ±2.0) mU/L , and increased insulin sensitivity index (ISI) from(-6.68±0.31) to(-5.07±0. 29) (P<0.05).(3) It greatly decreased total cholesterol (TC),triglyce ride (TG) and low density lipoprotein cholesterol (LDL C) from(6.88±0.54),(2. 85±0.31),and(4.12±0.2) to (5.82±0.48),(2.01±0.28), and(3.05±0.35) mmol /L,respectively,while increasing high density lipoprotein cholesterol (HDL C) level from(1.38±0.32) to(1.78±0.31) mmol/L.Conclusions Tang Z hi Xiao can significantly alleviate clinical symptoms,decrease FPG and adjust li pid content,which is probably relate to the improvement of insulin resistance ( IR).

关 键 词：糖脂消 代谢综合征 疗效研究 胰岛素敏感指数 糖尿病 胰岛素抵抗 高血脂 

分 类 号：R969[医药卫生—药理学]