紫草素、靛玉红对角质形成细胞凋亡的影响  

The effects of shikonin and indirubin on apoptosis of cultured keratinocytes

作　　者：王禾[1] 孙丽蕴[1] 邓丙戌[1] 王萍[1] 

机构地区：[1]北京中医医院皮肤性病科,100010

出　　处：《中国麻风皮肤病杂志》2003年第4期325-327,共3页China Journal of Leprosy and Skin Diseases

摘　　要：目的 :　探讨凉血活血胶囊 (liangxuehuoxuecapsule)治疗银屑病的机制。方法 :　采用流式细胞仪分析细胞亚二倍体含量和AnnexinV法分析细胞PS膜外化含量 ,观察凉血活血胶囊及其主要组成药物的主要成分紫草素 (shikonin)、靛玉红 (indirubin)对角质形成细胞凋亡的影响。结果 :　一定浓度的凉血活血胶囊及紫草素、靛玉红可诱导角质形成细胞凋亡。结论 :　诱导细胞凋亡可能是中药凉血活血胶囊治疗银屑病的作用机制之一。Objective: To investigate the effect of liangxuehuoxue capsule, shikonin and indirubin on apoptosis of keratinocytes.Methods: Flowing cytometry was used to analyze the content of hypodiploid in the cells and Annexin method was used to examine the effect of liangxuehuoxue capsule, shikonin and indirubin on apoptosis of cultured keratinocytes.Results: Liangxuehuoxue Capsule, shikonin and indirubin in some concentration could induce apoptosis. Conclusion: Induced apoptosis may be one of the major mechanisms of liangxuehuoxue capsule in the treatment of psoriasis.

关 键 词：紫草素 靛玉红 角质形成细胞 细胞凋亡 凉血活血胶囊 治疗 银屑病 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]