151例神经系统疾病脑脊液β_2—微球蛋白的放射免疫测定  

RADIOIMMUNOASSAY OF CEREBROSPINAL FLUID β_2-MICROGLOBULIN IN 151 PATIENTS WITH NERVOUS SYSTEM DISEASES

作　　者：邢永前[1] 巫志明[1] 凌蓓蒂[2] 陈富嫦[1] 薛瑶嫦 许志恩[1] 潘儒南 邹劲[1] 张俊徽[1] 周伟正[2] 莫凡[3] 

机构地区：[1]湛江医学院附属医院神经内科 [2]湛江医学院附属医院核医学科 [3]湛江医学院附属医院传染病科

出　　处：《湛江医学院学报》1992年第1期295-298,共4页

摘　　要：本文用放免法测定151例神经疾患病人和21例正常人CSF中β_2-微球蛋白含量。病变组包括急性脑血管病、颅内感染性疾病、脊髓疾病、症状性癫病和其他疾病。正常组均值为1.21μg/ml。病变组均值普遍增高,除急性脊髓炎之外与正常组对比均有显著性差异,但以出血性脑血管病、细菌或真菌性脑膜炎和脊髓压迫症者升高尤为显著。资料表明CSF中β_2-微球蛋白不适于做为特异性诊断指标,但对于同一组疾病中的各个病种之间的鉴别有一定的意义。The level of CSF β2-microglobulin(β2-m) was determinated in 151 patients with nervous system disease including acute cerebrovascular diseases, intracranial infection, spinal cord diseases, symptomatic epilepsy and others. The mean level of CSF β2-m in control was 1. 21μg/ml. Except the patients with acute myelitis, β2-m level of CSF in the patients with other diseases is significantly higher than that of the control,especially in the patients with hemorrhagic cerebrovascular diseases , meningitis of bacteria or mycotic organnism and compressive myelopathy. The result showed that the elevation of CSF β2-m level is not a specific diagnotic indicator,yet it is of some value in the differential diagnosis between hemorrhagic and ischemic cerebrovascular disease, bacteria and aseptic intracranial infection,compressive and noncompressive myelopathy.

关 键 词：脑脊液 β2 微球蛋白 神经系统病 

分 类 号：R446.14[医药卫生—诊断学]