保护L-丝氨酸和L-苏氨酸的合成  

Synthesis of Protected L-Serine and L-Tyrosine

作　　者：章平泉[1] 杜秀敏[1] 郭成[1] 

机构地区：[1]南京工业大学应用化学系,江苏南京210009

出　　处：《江苏化工》2004年第1期34-36,共3页Jiangsu Chemical Industry

摘　　要：采用对碱敏感的Fmoc基团和对酸敏感的叔丁基分别保护L-丝氨酸和L-苏氨酸的氨基和羟基,Fmoc基团用Fmoc-OSu引入,叔丁基在酸催化下用异丁烯引入,并对反应时间、温度和pH值加以优化,产物收率比文献值有了提高,产物纯度达到98%以上。In this article, the amido and hydroxyl of L-serine and L-tyrosine were protected using base-liable Fmoc group and acid-liable tert-butyl group respectively, and Fmoc -OSU could introduce Fmoc group while tert-butyl group was introduced by isobutene. Besides, the optimal reaction time, temperature and pH value were reported. The yield was enhanced than the literature reported and the purity was above 98%.

关 键 词：L-丝氨酸 L-苏氨酸 保护 合成 Fmoc基团 叔丁基 

分 类 号：TQ226.36[化学工程—有机化工]