HLA基因与成人急性淋巴细胞白血病的相关性研究  

ASSOCIATION OF HLA-ALLELES WITH ACUTE LYMPHOBLASTIC LEUKEMIA

作　　者：梁晓岚 杨丛林[1,2] 万长春[1] 谢云富[2] 钱小兵[2] 邱录贵[1,2] 

机构地区：[1]中国医学科学院,中国协和医科大学血液学研究所,血液病医院,天津300020 [2]天津市脐带血造血干细胞库,天津300073

出　　处：《白血病．淋巴瘤》2004年第1期17-19,共3页Journal of Leukemia & Lymphoma

基　　金：美国中华医学基金(CMB 01-748);天津市科委社发展基金(003119811)部分资助。

摘　　要：目的:探讨HLA基因与成人急性淋巴细胞白血病(ALL)发病之间的关联。方法:采用序列特异性引物聚合酶链反应(PCR蛳SSP)DNA分型技术,对105 例成人急性淋巴细胞白血病患者和142名正常对照进行HLA基因分型,分析HLA基因分布频率在2组中的差异。结果:ALL组与正常对照组相比,A鄢0201(35.71 %)和B鄢4801(5.71 %)基因频率明显增高(RR=2.340 7、7.513 4,χ2=9.257 8、9.538 8 P<0.005),DRB1鄢0701基因频率(9.52 %)显著低于正常组(RR=0.439 2,χ2=6.990 2 P<0.01)。结论:HLA蛳B鄢4801和DRB1鄢0701基因可分别被认为是ALL白血病发病的危险标志和保护标志。Objective:To investigate the correlation between the HLA genes and susceptibility of a-cute lymphoblastic leukemia(ALL).Methods:Polymerase chain reaction-specific sequence primers(PCR-SSP)method was used to HLA typing in the105patients with ALL and142normal subjects as control.Re-sults:A*0201(35.71%)and B*4801(5.71%)gene frequency in ALL patients were significantly higher than those in controls(RR=2.3407?7.5134,χ 2 =9.2578?9.5388P<0.005).In contrast,DRB1*0701(9.52%)gene frequency was significantly lower in ALL than that in controls(RR=0.4392,χ 2 =6.9902P<0.01).Conclusion:A*0201and HLA-B*4801forms may be considered the risk symbols while DRB1*0701be a protective symbol of ALL.

关 键 词：急性淋巴细胞白血病(ALL) HLA基因 基因频率 

分 类 号：R733.71[医药卫生—肿瘤]