脑复清胶囊对D-半乳糖致痴呆小鼠脑胆碱能系统的影响  被引量:1

Effects of Naofuqing Capsule on Cholinergic System in Demented Mice Induced By D-galactose

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作  者:刘超[1] 吴静[2] 王静[1] 杨军[1] 

机构地区:[1]安徽省医学科学研究所,安徽合肥230061 [2]解放军第105医院,安徽合肥230061

出  处:《中国中医药信息杂志》2004年第2期129-130,共2页Chinese Journal of Information on Traditional Chinese Medicine

基  金:安徽省"九五"科技攻关项目(9613010-1)

摘  要:目的观察脑复清胶囊对D-半乳糖致痴呆模型小鼠脑组织中乙酰胆碱酯酶和胆碱乙酰转移酶的影响。方法采用D-半乳糖造成小鼠痴呆模型,连续给药60d后,测定脑组织中乙酰胆碱酯酶和胆碱乙酰转移酶活性。结果脑复清胶囊可显著降低痴呆模型小鼠脑组织中乙酰胆碱酯酶活性,提高痴呆模型小鼠脑组织中胆碱乙酰转移酶活性。结论脑复清胶囊可能通过改善中枢胆碱能系统功能障碍来增强学习记忆能力。Objective To observe the effects of Naofuqing capsule on the activities of acetylcholinesterase and cholineacetyltransferase from brains in demented mice induced by D-galactose. Methods Demented mice induced by D-galactose were used and activities of acetylcholinesterase and cholineacetyltransferase from brains was determined. Results Naofuqing capsule could significantly decrease the activity of acetylcholinesterase and improve the activity of cholineacetyltransferase from brains in the demented mice. Conclusion Naofuqing capsule could improve the learning and memory ability through improving the dysfunction of cerebral cholinergic system.

关 键 词:脑复清胶囊 D-半乳糖 痴呆 小鼠 脑胆碱能系统 乙酰胆碱酯酶 胆碱乙酰转移酶 

分 类 号:R289.5[医药卫生—方剂学] R277.791[医药卫生—中药学]

 

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