微波促进Fries重排反应合成(2-羟基-5-甲基)苯基-1-十二酮  

Synthesis of (2-Hydroxy-5-methyl)phenyl-1-dodecanone by Microwave-enhanced Fries Rearrangement

作　　者：袁淑军[1] 吕春绪[1] 蔡春[1] 

机构地区：[1]南京理工大学化工学院

出　　处：《精细化工》2004年第3期230-231,237,共3页Fine Chemicals

摘　　要：在连续微波照射下,由十二酸对甲酚酯的Fries重排反应合成了(2 羟基 5 甲基)苯基 1 十二酮。通过对不同的溶剂、催化剂和反应时间的探索,发现与经典的反应相比,微波促进的反应在120℃下以硝基苯为溶剂、无水三氯化铝作催化剂时,反应时间由2h缩短到8min,收率由89 5%提高到93 4%。The Fries rearrangement of 4-methylphenyl dodecanoate was carried out under continuous microwave irradiation to form (2-hydroxy-5-methyl)phenyl-1-dodecanone.The reaction was steadily performed at 120 ℃ when nitrobenzene was used as the solvent and AlCl_3 as the catalyst.Compared with the classical method,yield of the reaction under microwave irradiation was raised from 89.5% to 93.4%,meanwhile the reaction time was shortened from 2 h to 8 min.

关 键 词：微波照射 FRIES重排 高级脂肪酸酚酯 (2-羟基-5-甲基)苯基-1-十二酮 

分 类 号：TQ244.2[化学工程—有机化工]