不稳定型心绞痛患者血清sICAM-1水平的变化及意义  

The Change and Clinical Significance of Serum sICAM-1 in Patients with UAP

作　　者：杨彬[1] 扈友庄[1] 刘东彪[1] 冯德辉[1] 

机构地区：[1]广东医学院附属医院,广东湛江524001

出　　处：《实用医技杂志》2004年第2期131-132,共2页Journal of Practical Medical Techniques

摘　　要：目的 :探讨不稳定型心绞痛 (UAP)患者血清中可溶性细胞间粘附分子 - 1(sICAM - 1)和C -反应蛋白(CRP)的水平与正常人的差异 ,及其在治疗前后的变化。方法 :通过酶联免疫吸附试验 (ELISA)法检测 6 4例UAP患者治疗前后血清sICAM - 1和CRP水平的变化 ,并与 2 2例正常对照组 (对照组 )对比分析。结果 :UAP患者血清sICAM -1和CRP水平较正常对照组明显升高 (均为P <0 .0 1) ,治疗后sICAM - 1及CRP水平较治疗前明显降低 (均为P <0 .0 1)。结论 :CRP、sICAM - 1可能参与了冠心病 (CHD)的发病过程 ,血清sICAM - 1的检测有助于临床病情分析。Objectve To observe the difference of the level of soluble intercellular adhesion molecule-1(sICAM-1), C reactive protein(CRP) between healthy people and the patients with unstable angina pectoris(UAP), also study their difference of UAP between before treatment and after treatment. Methods Measure serum level of sICAM-1 and CRP of the patients with UAP(before and after treatment) and healthy people(control group) by ELISA, and contract them. Results The serum level of sICAM-1 and CRP of patients with UAP were significantly higher that of control group(P<0.01); after treatment,the level of sICAM-1 and CRP of patients with UAP were significantly lower than that of untreatment(P<0.01). Conclusions The level of sICAM-1 and CRP maybe the risk factors of CHD and they are valuable index on predicting prognosis.

关 键 词：不稳定型心绞痛 血清 SICAM-1 C-反应蛋白 酶联免疫吸附试验 动脉粥样硬化 炎症反应 

分 类 号：R541.4[医药卫生—心血管疾病] R446.112[医药卫生—内科学]