长春新碱渗漏性损伤治疗方法的实验研究  

Experiment Study of the New Method for Treating Injury Caused by Extravasation of Vincrisine

作　　者：李立新[1] 陶金成[1] 陈炳英[1] 朱培莉[1] 

机构地区：[1]深圳市第二人民医院,深圳市518035

出　　处：《中国药房》2004年第3期145-146,共2页China Pharmacy

基　　金：深圳市科技计划资助项目 (200204080)

摘　　要：目的 :探讨2 %山莨菪碱加1 %利多卡因联合局部封闭治疗长春新碱渗漏性损伤的效果。方法 :对60只健康家兔 ,建立经耳静脉注射1 %长春新碱5ml,并人为渗漏到其皮下1ml致渗漏性损伤模型后 ,随机分为实验Ⅰ组、Ⅱ组和对照组。3组分别使用2 %山莨菪碱加1 %利多卡因、2 %山莨菪碱和0 9 %生理盐水局部封闭。结果 :治疗2wk后3组动物总有效率和治愈率分别为90 %和80 %、63 %和42 %、15 %和0 %。结论 :2 %山莨菪碱加1 %利多卡因局部封闭治疗长春新碱渗漏性损伤 ,在起效时间、治愈时间。OBJECTIVE:To observe the effect of2%anisodamine plus1%lidocaine block therapy on injury caused by extravasation of vincrisine.METHODS:60animal models were established by injecting1%vincrisine5ml into ear vein with1ml purposely extravasating to subcutaneous tissue in rabbits.The rabbits were divided randomly into groupⅠ,groupⅡand control group.GroupⅠreceived2%anisodamine+1%lidocaine,groupⅡ2%anisodamine and control group normal saline.RESULTS:After2weeks treatment,the total effective and curative rate in three groups were90%and80%,63%and42%,15%and0%respectively.CONCLUSION:2%anisodamine plus1%lidocaine block therapy is superior to normal saline in treating extravasation injury of vincrisine.

关 键 词：长春新碱 药物渗漏 山莨菪碱 利多卡因 

分 类 号：R979.1[医药卫生—药品]