伊曲康唑注射液治疗深部真菌感染  

Efficacy and safety of itraconazole injection in treatmeat of deep fungal infecfions

作　　者：蔡永宁[1] 梁德荣[1] 朱焕玲[2] 沈奇[1] 刘挺[2] 王霞[1] 黄杰[2] 

机构地区：[1]四川大学华西医院国家药品临床研究基地,成都610014 [2]四川大学华西医院血液科,成都610014

出　　处：《中国新药杂志》2004年第2期161-163,共3页Chinese Journal of New Drugs

摘　　要：目的:评价伊曲康唑注射液治疗深部真菌感染的有效性和安全性。方法:采用开放性临床研究,治疗深部真菌感染患者22例。确诊4例、拟诊10例、经验性治疗8例。剂量用法:d1-d2,伊曲康唑注射液200mg,iv,bid;d3-d14,200mg,iv,qd;d15-d42,改用伊曲康唑胶囊200mg,bid。结果:确诊和拟诊的14例患者真菌清除率为6/14,阴转率为6/14;综合疗效评价有效率为8/14,痊愈率为2/14。不良反应发生率为12/28。结论:伊曲康唑注射液治疗重症深部真菌感染安全有效。Objective: To evaluate the clinical efficacy and safety of itraconazole injection in treatment of deep fungal infections. Methods:The open clinical trial was conducted in 22 patients with deep fungal infection,including 4 cases of confirmed, 10 cases of suspected and 8 cases for empiric treatment. They were treated with iv itraconazole injection in a dose of 200mg twice daily in the first and the second days,from the third day to 14th day they were given iv itraconazole injection in a dose of 200mg once daily,and then treated with capsule in a dose of 200mg twice daily for another 28 days. Results: In confirmed and suspected patients, the eradication rate was 6/14 and the negative turning rate was 6/14. The effective rate was 8/14 and the cure rate was 2/14 by comprehensive evaluation. The incidence of adverse reaction was 12/28. Conclusion: Itraconazole injection is effective and safe in treatment of severe deep fungal infections.

关 键 词：伊曲康唑注射液 深部真菌感染 开放性临床研究 

分 类 号：R978.5[医药卫生—药品] R969.4[医药卫生—药学]